SCHEMBL14367376

SCHEMBL14367376

CCOC(=O)CCCN1CCN(CCCOc2ccc(C(=N)N)cc2)C(=O)C1=O

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ITGB3 P05106 1/20 0.47
ITGA2B P08514 1/20 0.47
PRSS1 P07477 7/20 0.46
TMPRSS2 O15393 2/20 0.46
HRH2 P25021 3/20 0.45
HRH1 P35367 3/20 0.45
PRMT1 Q99873 3/20 0.45
F2 P00734 2/20 0.45
ST14 Q9Y5Y6 2/20 0.45
KCNH2 Q12809 2/20 0.45
HRH3 Q9Y5N1 2/20 0.45
PLAU P00749 1/20 0.45
PRSS2 P07478 1/20 0.45
PRSS3 P35030 1/20 0.45
PRMT5 O14744 1/20 0.45
SLC22A2 O15244 1/20 0.45
SLC22A1 O15245 1/20 0.45
PTP4A3 O75365 1/20 0.45
SLC22A3 O75751 1/20 0.45
F10 P00742 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12461526 0.86 PRSS1 (0.61) PRSS1TMPRSS2PRMT1F2ST14
SCHEMBL14367374 0.85 PRSS1 (0.54) PRSS1TMPRSS2HRH2HRH1PRMT1
Acetic Acid SCHEMBL1715435 0.85 PRSS1 (0.54) ITGB3ITGA2BPRSS1TMPRSS2PRMT1
SCHEMBL14367370 0.85 PRSS1 (0.48) ITGB3ITGA2BPRSS1TMPRSS2PRMT1
SCHEMBL14367384 0.84 PRSS1 (0.58) PRSS1TMPRSS2PRMT1F2ST14
Hydrochloric Acid SCHEMBL1714025 0.84 PRSS1 (0.49) ITGB3ITGA2BPRSS1TMPRSS2PRMT1
SCHEMBL7752657 0.84 PRSS1 (0.61) PRSS1TMPRSS2PRMT1F2ST14
Acetic Acid SCHEMBL1714330 0.83 PRSS1 (0.51) ITGB3ITGA2BPRSS1TMPRSS2HRH2
SCHEMBL14367373 0.83 PRSS1 (0.54) PRSS1TMPRSS2PRMT1F2ST14
SCHEMBL1714662 0.83 PRMT1 (0.63) PRSS1TMPRSS2PRMT1F2ST14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7291617-B2 Arylamidine derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2007-11-06 US disclosed
US-7291617-B2 Arylamidine derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2007-11-06 US disclosed