SCHEMBL1436746

SCHEMBL1436746

N[C@@H](Cc1ccccc1)C(=O)C(Cl)C(=O)C(Cl)C(=O)[C@@H](N)Cc1ccccc1

nearest known ligand 0.63

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
SLC7A5 Q01650 2/20 0.63
ALPI P09923 1/20 0.63
PKM P14618 1/20 0.63
PTGS1 P23219 1/20 0.63
XIAP P98170 1/20 0.63
SLC15A1 P46059 1/20 0.54
LTA4H P09960 1/20 0.51
SLC1A3 P43003 2/20 0.50
SLC1A2 P43004 2/20 0.50
SLC1A1 P43005 2/20 0.50
HDAC8 Q9BY41 2/20 0.49
CYP1A2 P05177 1/20 0.47
EPHX1 P07099 2/20 0.47
CTSC P53634 1/20 0.46
LAP3 P28838 3/20 0.46
ANPEP P15144 2/20 0.46
SRR Q9GZT4 1/20 0.44
RNPEP Q9H4A4 1/20 0.44
DNPEP Q9ULA0 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7111513 1.00 SLC7A5 (0.63) SLC7A5ALPIPKMPTGS1XIAP
Hydrochloric Acid SCHEMBL5479690 0.98 SLC7A5 (0.61) SLC7A5ALPIPKMPTGS1XIAP
Hydrochloric Acid SCHEMBL5479695 0.98 SLC7A5 (0.61) SLC7A5ALPIPKMPTGS1XIAP
SCHEMBL28597069 0.86 SLC7A5 (0.76) SLC7A5ALPIPKMPTGS1XIAP
SCHEMBL30636861 0.81 ALPI (0.50) SLC7A5ALPIPKMPTGS1XIAP
Dl-Phenylalanine SCHEMBL28067572 0.81 SLC7A5 (0.88) SLC7A5ALPIPKMPTGS1XIAP
SCHEMBL13118180 0.81 SLC7A5 (0.68) SLC7A5ALPIPKMPTGS1XIAP
SCHEMBL1436733 0.81 SLC7A5 (0.58) SLC7A5ALPIPKMPTGS1XIAP
SCHEMBL1436736 0.81 SLC7A5 (0.58) SLC7A5ALPIPKMPTGS1XIAP
Hydrochloric Acid SCHEMBL5479700 0.80 SLC7A5 (0.56) SLC7A5ALPIPKMPTGS1XIAP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2014201111-A1 TREATMENT OF MTOR HYPERACTIVE RELATED DISEASES AND DISORDERS THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) 2014-12-18 WO disclosed
EP-2295082-B1 Method for producing catalytic antibodies (variants), antigens for immunization and nucleotide sequence FDS PHARMA ASS (GB) 2013-09-18 EP disclosed
EP-1394261-B1 ANTIGENS FOR IMMUNISATION FDS PHARMA ASS (GB) 2011-03-30 EP disclosed
EP-2295082-A1 Method for producing catalytic antibodies (variants), antigens for immunization and nucleotide sequence FDS Pharma Ass. (GB) 2011-03-16 EP disclosed
US-7560229-B2 Methods of use of the enzymes of mycothiol synthesis THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2009-07-14 US disclosed
US-7560529-B2 Method for producing catalytic antibodies (variants), antigens for immunization and nucleotide sequence FDS Pharma (GB) 2009-07-14 US disclosed
WO-2008078177-A2 METHOD FOR PRODUCING CATALYTIC ANTIBODIES (VARIANTS), ANTIGENS FOR IMMUNIZATION AND NUCLEOTIDE SEQUENCE FDS PHARMA ASS. (RU) 2008-07-03 WO disclosed
US-20070178109-A1 Method for producing catalytic antibodies (variants), antigens for immunization and nucleotide sequence LIFEBIO LABORATORIES LLC 2007-08-02 US disclosed
US-20060183116-A1 Methods of use of the enzymes of mycothiol synthesis UNIVERSITY OF BRITISH COLUMBIA (CA) 2006-08-17 US disclosed
EP-1601764-A2 A CLASS OF METACASPASES VIB vzw (BE) 2005-12-07 EP disclosed
US-20040265975-A1 glycoprotein 120; fusion proteins; myelin basic protein; autoimmune diseases; genetic vaccines FDS PHARMA ASS. (GB) 2004-12-30 US disclosed
WO-2004081168-A2 A CLASS OF METACASPASES VIB VZW (BE) 2004-09-23 WO disclosed
EP-1394261-A2 METHOD FOR PRODUCING CATALYTIC ANTIBODIES (VARIANTS), ANTIGENS FOR IMMUNISATION AND NUCLEOTIDE SEQUENCE ASGL - Farmatsevticjeskie Innovatsii, Zaptryote Aktsionernoe Obschestvo (RU) 2004-03-03 EP disclosed
WO-2003089585-A2 METHODS OF USE OF THE ENZYMES OF MYCOTHIOL SYNTHESIS THE REGENTS OF THE UNIVERISTY OF CALIFORNIA (US) 2003-10-30 WO disclosed
US-6242448-B1 Trisubstituted-oxazole derivatives as serotonin ligands AMERICAN HOME PRODUCTS CORPORATION 2001-06-05 US disclosed
EP-1053235-A1 OXAZOLE DERIVATIVES AS SEROTONIN-1A RECEPTOR AGONISTS AMERICAN HOME PRODUCTS CORPORATION (US) 2000-11-22 EP disclosed
US-6057340-A Oxazole derivatives as serotonin-1A receptor agonists AMERICAN HOME PRODUCTS CORPORATION (US) 2000-05-02 US disclosed
WO-1999038864-A1 OXAZOLE DERIVATIVES AS SEROTONIN-1A RECEPTOR AGONISTS AMERICAN HOME PRODUCTS CORPORATION (US) 1999-08-05 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070178109-A1 Method for producing catalytic antibodies (variants), antigens for immunization and nucleotide sequence SSB, DNMT3L, NASP SLC7A5 4534/4885ALPI 1231/4885PKM 4045/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.