Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AB1 | P08238 | 19/20 | 0.66 |
| ▸ | HSP90AA1 | P07900 | 18/20 | 0.66 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.66 |
| ▸ | TRAP1 | Q12931 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4566954 | 0.94 | HSP90AB1 (0.62) | HSP90AB1HSP90AA1HSP90B1TRAP1 | |
| SCHEMBL4566951 | 0.89 | HSP90AB1 (0.61) | HSP90AB1HSP90AA1HSP90B1TRAP1 | |
| SCHEMBL4566935 | 0.89 | HSP90AA1 (0.65) | HSP90AB1HSP90AA1HSP90B1TRAP1 | |
| SCHEMBL4566949 | 0.89 | HSP90AB1 (0.60) | HSP90AB1HSP90AA1HSP90B1TRAP1 | |
| SCHEMBL4566947 | 0.87 | HSP90AB1 (0.59) | HSP90AB1HSP90AA1HSP90B1TRAP1 | |
| SCHEMBL4566942 | 0.87 | HSP90AB1 (0.59) | HSP90AB1HSP90AA1HSP90B1TRAP1 | |
| SCHEMBL14367978 | 0.86 | HSP90AB1 (0.58) | HSP90AB1HSP90AA1HSP90B1TRAP1 | |
| SCHEMBL14367675 | 0.85 | HSP90AA1 (0.55) | HSP90AB1HSP90AA1HSP90B1TRAP1 | |
| SCHEMBL4566956 | 0.85 | HSP90AB1 (0.64) | HSP90AB1HSP90AA1HSP90B1TRAP1 | |
| SCHEMBL4566948 | 0.85 | HSP90AB1 (0.64) | HSP90AB1HSP90AA1HSP90B1TRAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007139955-A2 | TRIAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY | SYNTA PHARMACEUTICALS CORP. (US) | 2007-12-06 | — | — | WO | disclosed |