Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL941950 | 0.90 | — | — | |
| SCHEMBL1617155 | 0.63 | — | — | |
| SCHEMBL251119 | 0.63 | — | — | |
| Iodide SCHEMBL9450704 | 0.60 | — | — | |
| Iodide SCHEMBL2080763 | 0.60 | — | — | |
| SCHEMBL10387811 | 0.60 | — | — | |
| Bromide SCHEMBL20139599 | 0.60 | — | — | |
| Iodide SCHEMBL2359394 | 0.60 | — | — | |
| Iodide SCHEMBL21379237 | 0.60 | — | — | |
| SCHEMBL1326414 | 0.60 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9796697-B2 | Tricyclic inhibitors of HIF-2-alpha and uses thereof | PELOTON THERAPEUTICS, INC. (US) | 2017-10-24 | — | — | US | disclosed |
| US-20160362390-A1 | TRICYCLIC INHIBITORS OF HIF-2-ALPHA AND USES THEREOF | PELOTON THERAPEUTICS, INC. | 2016-12-15 | — | — | US | disclosed |
| WO-2011023791-A2 | METHOD FOR PRODUCING ORGANOALUMINIUM COMPOUNDS AND USE THEREOF | LUDWIG-MAXIMILIANS-UNIVERSITÄT MÜNCHEN (DE) | 2011-03-03 | — | — | WO | disclosed |