Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
| ▸ | CDK4 | P11802 | 2/20 | 0.43 |
| ▸ | CDK2 | P24941 | 2/20 | 0.43 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | COMT | P21964 | 12/20 | 0.42 |
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.36 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14401137 | 0.80 | CDK4 (0.47) | CDK4CDK2CCNE1LMNAHTT | |
| SCHEMBL27015063 | 0.72 | DYRK1A (0.48) | DYRK1AHTTNPC1POLBRAB9A | |
| SCHEMBL14335635 | 0.69 | DYRK1A (0.41) | DYRK1AMEN1KMT2APOLB | |
| SCHEMBL28466268 | 0.69 | DYRK1A (0.44) | DYRK1ALMNAHTTNPC1MEN1 | |
| SCHEMBL5717577 | 0.68 | CDK4 (0.38) | CDK4CDK2CCNE1LMNAHTT | |
| SCHEMBL27599944 | 0.68 | CDK4 (0.38) | CDK4CDK2CCNE1LMNAHTT | |
| SCHEMBL27015076 | 0.68 | PDE10A (0.45) | DYRK1ACDK2MEN1KMT2A | |
| SCHEMBL26038672 | 0.67 | GRM6 (0.38) | DYRK1ALMNA | |
| SCHEMBL26038613 | 0.67 | DYRK1A (0.35) | DYRK1A | |
| SCHEMBL26043404 | 0.67 | GRM6 (0.41) | DYRK1ALMNAMEN1KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7279474-B2 | Substituted pyrrolo[2,3-d]pyrimidines as antagonists of the corticotropin releasing factor (CRF) | GLAXO GROUP LIMITED (GB) | 2007-10-09 | — | — | US | disclosed |