Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 10/20 | 0.48 |
| ▸ | KIT | P10721 | 6/20 | 0.46 |
| ▸ | PDGFRA | P16234 | 6/20 | 0.46 |
| ▸ | KDR | P35968 | 2/20 | 0.45 |
| ▸ | ABL1 | P00519 | 4/20 | 0.44 |
| ▸ | BCR | P11274 | 4/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.44 |
| ▸ | RAF1 | P04049 | 3/20 | 0.44 |
| ▸ | BRAF | P15056 | 3/20 | 0.44 |
| ▸ | PLK4 | O00444 | 1/20 | 0.43 |
| ▸ | DDX3X | O00571 | 1/20 | 0.43 |
| ▸ | GAK | O14976 | 1/20 | 0.43 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.43 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.43 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14375836 | 0.93 | MAPK14 (0.43) | MAPK14KITPDGFRAABL1BCR | |
| SCHEMBL14375898 | 0.85 | PDGFRA (0.51) | MAPK14KITPDGFRAKDRABL1 | |
| SCHEMBL14375872 | 0.84 | PDGFRA (0.60) | MAPK14KITPDGFRAKDRABL1 | |
| SCHEMBL14375833 | 0.82 | PDGFRA (0.71) | MAPK14KITPDGFRAKDRABL1 | |
| SCHEMBL14375827 | 0.82 | MAPK14 (0.49) | MAPK14KITPDGFRAKDRABL1 | |
| SCHEMBL14375829 | 0.79 | MAPK14 (0.52) | MAPK14KITPDGFRAKDRABL1 | |
| SCHEMBL14375799 | 0.79 | ABL1 (0.58) | MAPK14KITPDGFRAKDRABL1 | |
| SCHEMBL14375823 | 0.78 | MAPK14 (0.52) | MAPK14KITPDGFRAKDRABL1 | |
| SCHEMBL14375923 | 0.78 | ABL1 (0.43) | KITPDGFRAKDRABL1BCR | |
| SCHEMBL14375886 | 0.75 | ABL1 (0.60) | MAPK14KITPDGFRAKDRABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7279576-B2 | Anti-cancer medicaments | DECIPHERA PHARMACEUTICALS, LLC (US) | 2007-10-09 | — | — | US | disclosed |