Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 2/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.46 |
| ▸ | SMO | Q99835 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NMT1 | P30419 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14349217 | 0.90 | MAP4K4 (0.49) | MAP4K4HDAC1HRH3KMT2ANMT1 | |
| SCHEMBL8281725 | 0.81 | MAP4K4 (0.51) | MAP4K4HDAC1HRH3NMT1ADRA1A | |
| SCHEMBL11989568 | 0.79 | MAP4K4 (0.45) | MAP4K4HDAC1HRH3KMT2ANMT1 | |
| SCHEMBL11989565 | 0.79 | MAP4K4 (0.45) | MAP4K4HDAC1HRH3KMT2ANMT1 | |
| SCHEMBL23263993 | 0.79 | MAP4K4 (0.51) | MAP4K4HDAC1HRH3NMT1ADRA1A | |
| SCHEMBL30294197 | 0.79 | MAP4K4 (0.51) | MAP4K4HDAC1HRH3NMT1ADRA1A | |
| SCHEMBL14147068 | 0.78 | MAP4K4 (0.48) | MAP4K4HDAC1HRH3KMT2ANMT1 | |
| SCHEMBL14375965 | 0.78 | MAP4K4 (0.48) | MAP4K4HDAC1HRH3NMT1ADRA1A | |
| SCHEMBL15247202 | 0.78 | MAP4K4 (0.48) | MAP4K4HDAC1HRH3KMT2ANMT1 | |
| SCHEMBL14349686 | 0.78 | MAP4K4 (0.48) | MAP4K4HDAC1HRH3KMT2ANMT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7312209-B2 | Acridone inhibitors of IMPDH enzyme | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-12-25 | — | — | US | disclosed |