Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 11/20 | 0.71 |
| ▸ | HDAC1 | Q13547 | 10/20 | 0.71 |
| ▸ | PPARG | P37231 | 4/20 | 0.56 |
| ▸ | IDO1 | P14902 | 1/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.55 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.55 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.54 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.54 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.54 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.54 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.54 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.50 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14376804 | 0.88 | HDAC6 (0.71) | HDAC6HDAC1PPARGIDO1HDAC8 | |
| SCHEMBL14376779 | 0.86 | HDAC6 (0.70) | HDAC6HDAC1PPARGIDO1HDAC8 | |
| SCHEMBL14376776 | 0.86 | HDAC6 (0.70) | HDAC6HDAC1PPARGIDO1HDAC8 | |
| SCHEMBL1608399 | 0.85 | HDAC6 (0.67) | HDAC6HDAC1PPARGIDO1HDAC8 | |
| SCHEMBL14376815 | 0.83 | HDAC6 (0.65) | HDAC6HDAC1HDAC8HDAC3HDAC2 | |
| SCHEMBL12850040 | 0.83 | HDAC6 (1.00) | HDAC6HDAC1IDO1HDAC8HDAC2 | |
| SCHEMBL13187230 | 0.82 | CYP11B1 (0.71) | PPARGIDO1KCNH2CYP11B1CYP11B2 | |
| SCHEMBL8032078 | 0.81 | PPARG (0.62) | HDAC6HDAC1PPARGIDO1KCNH2 | |
| SCHEMBL8042067 | 0.79 | PPARG (0.60) | HDAC6HDAC1PPARGIDO1KCNH2 | |
| SCHEMBL1607561 | 0.79 | HDAC1 (0.62) | HDAC6HDAC1IDO1HDAC3HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150197497-A1 | SELECTIVE INHIBITORS OF HISTONE DEACETYLASE ISOFORM 6 AND METHODS THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2015-07-16 | — | — | US | disclosed |
| US-20150197497-A1 | SELECTIVE INHIBITORS OF HISTONE DEACETYLASE ISOFORM 6 AND METHODS THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2015-07-16 | — | — | US | disclosed |
| WO-2012178208-A2 | SELECTIVE INHIBITORS OF HISTONE DEACETYLASE ISOFORM 6 AND METHODS THEREOF | THE TRUSTEES OF THE STEVENS INSTITUTE OF TECHNOLOGY (US) | 2012-12-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150197497-A1 | SELECTIVE INHIBITORS OF HISTONE DEACETYLASE ISOFORM 6 AND METHODS THEREOF | HDAC6, HDAC5, HDAC1 | HDAC6 1/4885HDAC1 3/4885PPARG 1739/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.