Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | GRN | P28799 | 5/20 | 0.39 |
| ▸ | SORT1 | Q99523 | 5/20 | 0.39 |
| ▸ | CDK8 | P49336 | 2/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
| ▸ | LTK | P29376 | 1/20 | 0.35 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.35 |
| ▸ | CLK2 | P49760 | 1/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.35 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.32 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.32 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20603916 | 0.80 | GRN (0.47) | KDM4EGRNSORT1CDK8AURKA | |
| SCHEMBL4139015 | 0.80 | KDM4E (0.44) | KDM4EGRNSORT1CDK8AURKA | |
| SCHEMBL667656 | 0.74 | KDM4E (0.40) | KDM4EGRNSORT1CDK8AURKA | |
| SCHEMBL15046195 | 0.73 | KDM4E (0.44) | KDM4EGRNSORT1CDK8AURKA | |
| SCHEMBL13265589 | 0.73 | KDM4E (0.44) | KDM4EGRNSORT1CDK8AURKA | |
| Hydrochloric Acid SCHEMBL9121760 | 0.71 | KDM4E (0.42) | KDM4EGRNSORT1CDK8AURKA | |
| Oxalic Acid SCHEMBL1013112 | 0.68 | GRN (0.44) | KDM4EGRNSORT1CDK8AURKA | |
| SCHEMBL432964 | 0.65 | KDM4E (0.50) | KDM4EGRNSORT1MAPK14CNR2 | |
| SCHEMBL3843249 | 0.65 | KDM4E (0.46) | KDM4EGRNSORT1ALDH1A1CNR1 | |
| SCHEMBL21643577 | 0.65 | KDM4E (0.33) | KDM4EGRNSORT1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070244120-A1 | INHIBITION OF RAF KINASE USING SUBSTITUTED HETEROCYCLIC UREAS | BAYER HEALTHCARE LLC | 2007-10-18 | — | — | US | disclosed |
| US-20070244120-A1 | INHIBITION OF RAF KINASE USING SUBSTITUTED HETEROCYCLIC UREAS | BAYER HEALTHCARE LLC | 2007-10-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070244120-A1 | INHIBITION OF RAF KINASE USING SUBSTITUTED HETEROCYCLIC UREAS | BRAF, RAF1, ARAF | KDM4E 1353/4885GRN 4542/4885SORT1 4757/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.