Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 20/20 | 0.75 |
| ▸ | EDNRB | P24530 | 19/20 | 0.75 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.64 |
| ▸ | TSPO | P30536 | 1/20 | 0.64 |
| ▸ | DRD3 | P35462 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14380477 | 0.92 | EDNRA (0.84) | EDNRAEDNRBSLC6A2TSPODRD3 | |
| SCHEMBL14380493 | 0.92 | EDNRA (0.72) | EDNRAEDNRBSLC6A2TSPODRD3 | |
| SCHEMBL14380473 | 0.91 | EDNRA (0.72) | EDNRAEDNRBSLC6A2TSPODRD3 | |
| SCHEMBL14380480 | 0.89 | EDNRB (0.78) | EDNRAEDNRBSLC6A2TSPODRD3 | |
| SCHEMBL14380472 | 0.87 | EDNRA (0.73) | EDNRAEDNRBSLC6A2TSPODRD3 | |
| SCHEMBL14380491 | 0.86 | EDNRA (0.85) | EDNRAEDNRBSLC6A2TSPODRD3 | |
| SCHEMBL14380521 | 0.86 | EDNRA (1.00) | EDNRAEDNRBSLC6A2TSPODRD3 | |
| SCHEMBL8351145 | 0.86 | EDNRA (0.86) | EDNRAEDNRBSLC6A2TSPODRD3 | |
| SCHEMBL14380497 | 0.86 | EDNRA (0.72) | EDNRAEDNRBSLC6A2TSPODRD3 | |
| SCHEMBL14380527 | 0.86 | EDNRA (0.85) | EDNRAEDNRBSLC6A2TSPODRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7285549-B2 | Sulfamides and their use as endothelin receptor antagonists | ACTELION PHARMACEUTICALS LTD. (CH) | 2007-10-23 | — | — | US | disclosed |
| US-7285549-B2 | Sulfamides and their use as endothelin receptor antagonists | ACTELION PHARMACEUTICALS LTD. (CH) | 2007-10-23 | — | — | US | disclosed |