Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 13/20 | 0.61 |
| ▸ | EDNRB | P24530 | 12/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 3/20 | 0.42 |
| ▸ | CA7 | P43166 | 1/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14380571 | 0.92 | EDNRB (0.58) | EDNRAEDNRBMEN1KMT2ACA12 | |
| SCHEMBL5631309 | 0.91 | EDNRA (0.63) | EDNRAEDNRBMEN1KMT2ACA12 | |
| SCHEMBL14380560 | 0.90 | EDNRA (0.62) | EDNRAEDNRBCA12CA2CA7 | |
| SCHEMBL14380569 | 0.89 | EDNRB (0.50) | EDNRAEDNRBMEN1KMT2ACA12 | |
| SCHEMBL31442543 | 0.89 | EDNRA (0.64) | EDNRAEDNRBCA12CA2CA7 | |
| SCHEMBL14380566 | 0.89 | EDNRA (0.64) | EDNRAEDNRBCA12CA2CA7 | |
| SCHEMBL14380564 | 0.82 | EDNRA (0.43) | EDNRAEDNRBMEN1KMT2A | |
| SCHEMBL14380582 | 0.81 | PDE5A (0.48) | EDNRAEDNRBMEN1KMT2AATM | |
| SCHEMBL5631186 | 0.79 | EDNRA (0.39) | EDNRAEDNRBMEN1KMT2ACYP3A4 | |
| SCHEMBL14380559 | 0.79 | EDNRB (0.57) | EDNRAEDNRBMEN1KMT2ACA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7285549-B2 | Sulfamides and their use as endothelin receptor antagonists | ACTELION PHARMACEUTICALS LTD. (CH) | 2007-10-23 | — | — | US | disclosed |
| US-7285549-B2 | Sulfamides and their use as endothelin receptor antagonists | ACTELION PHARMACEUTICALS LTD. (CH) | 2007-10-23 | — | — | US | disclosed |