Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 13/20 | 0.56 |
| ▸ | PIK3CA | P42336 | 16/20 | 0.55 |
| ▸ | CDK8 | P49336 | 1/20 | 0.49 |
| ▸ | PARP1 | P09874 | 3/20 | 0.44 |
| ▸ | PLK4 | O00444 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | ROS1 | P08922 | 1/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
| ▸ | FLT1 | P17948 | 1/20 | 0.43 |
| ▸ | MARK3 | P27448 | 1/20 | 0.43 |
| ▸ | FLT4 | P35916 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
| ▸ | CLK2 | P49760 | 1/20 | 0.43 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.43 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.43 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.43 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1857295 | 0.89 | MTOR (0.56) | MTORPIK3CACDK8PARP1PLK4 | |
| SCHEMBL1858651 | 0.88 | MTOR (0.60) | MTORPIK3CAPARP1PLK4JAK2 | |
| SCHEMBL4439967 | 0.86 | MTOR (0.73) | MTORPIK3CAPARP1PIK3CDPIK3CB | |
| SCHEMBL1864876 | 0.86 | PIK3CA (0.52) | MTORPIK3CAPARP1PLK4JAK2 | |
| SCHEMBL14384606 | 0.86 | PIK3CA (0.54) | MTORPIK3CAPARP1PLK4JAK2 | |
| SCHEMBL1860358 | 0.85 | MTOR (0.75) | MTORPIK3CACDK8PARP1PLK4 | |
| SCHEMBL2869632 | 0.84 | MTOR (0.64) | MTORPIK3CACDK8PARP1PLK4 | |
| SCHEMBL1859264 | 0.84 | MTOR (0.56) | MTORPIK3CACDK8PARP1PLK4 | |
| SCHEMBL14384602 | 0.84 | PIK3CA (0.68) | MTORPIK3CAPARP1PLK4JAK2 | |
| SCHEMBL1868435 | 0.83 | PIK3CA (0.78) | MTORPIK3CAPARP1PLK4JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2046799-B1 | PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | GENENTECH INC (US) | 2017-07-19 | — | — | EP | disclosed |
| WO-2007127183-A1 | PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | GENENTECH, INC. (US) | 2007-11-08 | — | — | WO | disclosed |