Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 7/20 | 0.68 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 2/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | PPARD | Q03181 | 1/20 | 0.37 |
| ▸ | RAF1 | P04049 | 1/20 | 0.36 |
| ▸ | DHODH | Q02127 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | ATM | Q13315 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4820432 | 0.88 | FFAR1 (0.74) | FFAR1CYP2C9KCNH2CACNA1CRAF1 | |
| SCHEMBL4864522 | 0.88 | FFAR1 (0.74) | FFAR1CYP2C9KCNH2CACNA1CRAF1 | |
| SCHEMBL4864532 | 0.88 | FFAR1 (0.74) | FFAR1CYP2C9KCNH2CACNA1CRAF1 | |
| SCHEMBL14018138 | 0.87 | FFAR1 (0.72) | FFAR1CYP2C9KCNH2CACNA1CRAF1 | |
| SCHEMBL14018104 | 0.86 | FFAR1 (0.76) | FFAR1CYP2C9RAF1CYP1A2CYP2C19 | |
| SCHEMBL4827540 | 0.86 | FFAR1 (0.76) | FFAR1CYP2C9RAF1CYP1A2CYP2C19 | |
| SCHEMBL4823796 | 0.84 | FFAR1 (0.79) | FFAR1CYP2C9PPARAPPARGPPARD | |
| SCHEMBL14391978 | 0.81 | FFAR1 (0.61) | FFAR1CYP2C9KCNH2CACNA1CPPARG | |
| SCHEMBL4826669 | 0.81 | FFAR1 (0.72) | FFAR1RAF1PTGDR2BRAF | |
| SCHEMBL14391971 | 0.81 | FFAR1 (0.72) | FFAR1RAF1PTGDR2BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007136572-A2 | ANTIDIABETIC BICYCLIC COMPOUNDS | MERCK & CO., INC. (US) | 2007-11-29 | — | — | WO | disclosed |
| WO-2007136573-A2 | ANTIDIABETIC BICYCLIC COMPOUNDS | MERCK & CO., INC. (US) | 2007-11-29 | — | — | WO | disclosed |