Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 9/20 | 0.65 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.53 |
| ▸ | S1PR3 | Q99500 | 5/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | S1PR5 | Q9H228 | 3/20 | 0.47 |
| ▸ | CYSLTR2 | Q9NS75 | 4/20 | 0.47 |
| ▸ | CYSLTR1 | Q9Y271 | 4/20 | 0.47 |
| ▸ | CNR2 | P34972 | 1/20 | 0.47 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.44 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1438125 | 0.97 | S1PR1 (0.69) | S1PR1FFAR1S1PR3MEN1KMT2A | |
| Trifluoroacetic Acid SCHEMBL1438624 | 0.94 | S1PR1 (0.59) | S1PR1FFAR1S1PR3MEN1KMT2A | |
| SCHEMBL1437860 | 0.94 | S1PR1 (0.61) | S1PR1FFAR1S1PR3MEN1KMT2A | |
| SCHEMBL1439234 | 0.93 | S1PR1 (0.56) | S1PR1S1PR3MEN1KMT2ACNR2 | |
| Trifluoroacetic Acid SCHEMBL12003495 | 0.92 | S1PR1 (0.62) | S1PR1FFAR1S1PR3MEN1KMT2A | |
| SCHEMBL1438800 | 0.91 | S1PR1 (0.56) | S1PR1S1PR3MEN1KMT2ACNR2 | |
| SCHEMBL1439363 | 0.90 | S1PR1 (0.54) | S1PR1S1PR3MEN1KMT2ACNR2 | |
| SCHEMBL1438123 | 0.89 | S1PR1 (0.52) | S1PR1FFAR1S1PR3MEN1KMT2A | |
| Trifluoroacetic Acid SCHEMBL1436939 | 0.89 | S1PR1 (0.56) | S1PR1FFAR1S1PR3MEN1KMT2A | |
| SCHEMBL1438859 | 0.88 | S1PR1 (0.57) | S1PR1FFAR1S1PR3MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9045441-B2 | (Thio)morpholine derivatives as S1P modulators | ABBVIE BAHAMAS LIMITED (BS) | 2015-06-02 | — | — | US | claimed |
| EP-2473490-B1 | (THIO)MORPHOLINE DERIVATIVES AS S1P MODULATORS | ABBVIE BAHAMAS LTD (BS) | 2014-02-26 | — | — | EP | claimed |
| US-20120220552-A1 | (THIO)MORPHOLINE DERIVATIVES AS S1P MODULATORS | ABBVIE BAHAMAS LIMITED (BS) | 2012-08-30 | — | — | US | claimed |
| EP-2473490-A1 | (THIO)MORPHOLINE DERIVATIVES AS S1P MODULATORS | Abbott Healthcare Products B.V. (NL) | 2012-07-11 | — | — | EP | claimed |
| CN-102548976-A | (Thio) morpholine derivatives as S1P modulators | ABBOTT HEALTHCARE PRODUCTS BV | 2012-07-04 | — | — | CN | claimed |
| WO-2011023795-A1 | (THIO)MORPHOLINE DERIVATIVES AS S1P MODULATORS | ABBOTT HEALTHCARE PRODUCTS B.V. (NL) | 2011-03-03 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120220552-A1 | (THIO)MORPHOLINE DERIVATIVES AS S1P MODULATORS | S1PR3, S1PR1, S1PR2 | S1PR1 2/4885FFAR1 530/4885S1PR3 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.