Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 7/20 | 0.57 |
| ▸ | JUN | P05412 | 2/20 | 0.57 |
| ▸ | MAPK8 | P45983 | 7/20 | 0.43 |
| ▸ | MAPK9 | P45984 | 5/20 | 0.42 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.39 |
| ▸ | CDK2 | P24941 | 3/20 | 0.39 |
| ▸ | CCND1 | P24385 | 2/20 | 0.39 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.39 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.39 |
| ▸ | GSK3A | P49840 | 2/20 | 0.38 |
| ▸ | GSK3B | P49841 | 2/20 | 0.38 |
| ▸ | AXL | P30530 | 2/20 | 0.37 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.37 |
| ▸ | MERTK | Q12866 | 2/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL559527 | 0.83 | MAPK10 (0.57) | MAPK10JUNMAPK8MAPK9CCNE1 | |
| SCHEMBL559503 | 0.83 | MAPK10 (0.57) | MAPK10JUNMAPK8MAPK9RIPK2 | |
| SCHEMBL559502 | 0.83 | MAPK10 (0.57) | MAPK10JUNMAPK8MAPK9RIPK2 | |
| SCHEMBL559526 | 0.83 | MAPK10 (0.57) | MAPK10JUNMAPK8MAPK9CCNE1 | |
| SCHEMBL558932 | 0.75 | MAPK10 (0.72) | MAPK10JUNMAPK8MAPK9RIPK2 | |
| SCHEMBL559509 | 0.75 | MAPK10 (0.76) | MAPK10JUNMAPK8MAPK9RIPK2 | |
| SCHEMBL559508 | 0.75 | MAPK10 (0.76) | MAPK10JUNMAPK8MAPK9RIPK2 | |
| SCHEMBL558933 | 0.75 | MAPK10 (0.72) | MAPK10JUNMAPK8MAPK9RIPK2 | |
| SCHEMBL560048 | 0.74 | MAPK10 (0.75) | MAPK10JUNMAPK8MAPK9RIPK2 | |
| SCHEMBL560047 | 0.74 | MAPK10 (0.75) | MAPK10JUNMAPK8MAPK9RIPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007125405-A2 | SUBSTITUTED 2-AMINO-FUSED HETEROCYCLIC COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2007-11-08 | — | — | WO | disclosed |