Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.62 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.53 |
| ▸ | CA12 | O43570 | 1/20 | 0.51 |
| ▸ | CA1 | P00915 | 1/20 | 0.51 |
| ▸ | CA2 | P00918 | 1/20 | 0.51 |
| ▸ | CA9 | Q16790 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.47 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | FPR3 | P25089 | 1/20 | 0.46 |
| ▸ | FPR2 | P25090 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14450277 | 0.85 | EPHX1 (0.68) | EPHX1EPHX2CA12CA1CA2 | |
| SCHEMBL3911344 | 0.82 | EPHX1 (0.65) | EPHX1EPHX2CA12CA1CA2 | |
| SCHEMBL26131308 | 0.82 | EPHX1 (0.74) | EPHX1EPHX2ALDH1A1NPC1MAPT | |
| SCHEMBL10165816 | 0.82 | EPHX1 (0.65) | EPHX1EPHX2CA12CA1CA2 | |
| SCHEMBL1514783 | 0.82 | EPHX1 (0.64) | EPHX1EPHX2ALDH1A1NPC1MAPK1 | |
| Hydrochloric Acid SCHEMBL538324 | 0.81 | EPHX1 (0.63) | EPHX1EPHX2CA12CA1CA2 | |
| SCHEMBL18926997 | 0.80 | EPHX1 (0.70) | EPHX1EPHX2CA12CA1CA2 | |
| SCHEMBL2014950 | 0.80 | EPHX1 (0.70) | EPHX1EPHX2CA12CA1CA2 | |
| SCHEMBL1437840 | 0.79 | EPHX1 (0.74) | EPHX1EPHX2ALDH1A1NPC1MAPK1 | |
| SCHEMBL2016955 | 0.79 | EPHX1 (0.68) | EPHX1EPHX2CA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007123892-A2 | RAF INHIBITORS AND THEIR USES | ARQULE INC. (US) | 2007-11-01 | — | — | WO | disclosed |