Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR3 | P51677 | 15/20 | 0.43 |
| ▸ | KDM2B | Q8NHM5 | 2/20 | 0.41 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.41 |
| ▸ | HTR3B | O95264 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.41 |
| ▸ | HTR3A | P46098 | 1/20 | 0.41 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.41 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14368942 | 1.00 | CCR3 (0.43) | CCR3KDM2BHTR3EHTR3BALOX15 | |
| SCHEMBL14368941 | 0.91 | CCR3 (0.53) | CCR3CYP2D6DRD2SLC6A2HTR2A | |
| SCHEMBL14368938 | 0.91 | CCR3 (0.49) | CCR3CYP2D6DRD2SLC6A2HTR2A | |
| SCHEMBL14392511 | 0.90 | CCR3 (0.53) | CCR3KDM2BCYP2D6DRD2SLC6A2 | |
| SCHEMBL14368823 | 0.90 | CCR3 (0.53) | CCR3KDM2BCYP2D6DRD2SLC6A2 | |
| SCHEMBL5663662 | 0.90 | CCR3 (0.46) | CCR3KDM2B | |
| SCHEMBL5663658 | 0.90 | CCR3 (0.46) | CCR3KDM2B | |
| SCHEMBL4428303 | 0.88 | CCR3 (0.46) | CCR3KDM2BHTR3EHTR3BALOX15 | |
| SCHEMBL4552919 | 0.88 | CHKA (0.44) | CCR3CYP2D6DRD2SLC6A2HTR2A | |
| SCHEMBL4552920 | 0.88 | CHKA (0.44) | CCR3CYP2D6DRD2SLC6A2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007126362-A1 | COMPOUNDS THAT ARE AGONISTS OF MUSCARINIC RECEPTORS AND THAT MAY BE EFFECTIVE IN TREATING PAIN, ALZHEIMER'S DISEASE AND/OR SCHIZOPHRENIA | ASTRAZENECA AB (SE) | 2007-11-08 | — | — | WO | disclosed |