Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHB4 | P54760 | 2/20 | 0.40 |
| ▸ | KDR | P35968 | 12/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3922932 | 0.85 | KDR (0.39) | EPHB4KDRFGFR1MAPK14 | |
| SCHEMBL5914429 | 0.81 | EPHB4 (0.42) | EPHB4KDRFGFR1MAPK14 | |
| SCHEMBL5314939 | 0.80 | KDR (0.40) | EPHB4KDRFGFR1MAPK14 | |
| SCHEMBL5317833 | 0.80 | KDR (0.40) | EPHB4KDRFGFR1MAPK14 | |
| SCHEMBL5266372 | 0.79 | EPHB4 (0.44) | EPHB4KDRFGFR1MAPK14 | |
| SCHEMBL5914084 | 0.78 | KDR (0.37) | EPHB4KDRFGFR1MAPK14 | |
| SCHEMBL5914097 | 0.78 | KDR (0.37) | EPHB4KDRFGFR1MAPK14 | |
| SCHEMBL5914022 | 0.78 | KDR (0.37) | EPHB4KDRFGFR1MAPK14 | |
| SCHEMBL3926763 | 0.78 | DPP4 (0.36) | EPHB4KDRFGFR1MAPK14 | |
| SCHEMBL3927419 | 0.77 | KDR (0.33) | EPHB4KDRFGFR1MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007114827-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2007-10-11 | — | — | WO | disclosed |