Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 15/20 | 0.60 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.54 |
| ▸ | KIT | P10721 | 4/20 | 0.54 |
| ▸ | PDGFRA | P16234 | 4/20 | 0.54 |
| ▸ | FLT3 | P36888 | 4/20 | 0.54 |
| ▸ | ABL1 | P00519 | 1/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14396835 | 0.91 | CSF1R (0.59) | CSF1RPDGFRBKITPDGFRAFLT3 | |
| SCHEMBL14396649 | 0.89 | CSF1R (0.54) | CSF1RPDGFRBKITPDGFRAFLT3 | |
| SCHEMBL2676949 | 0.88 | CSF1R (0.64) | CSF1RPDGFRBKITPDGFRAFLT3 | |
| SCHEMBL19415479 | 0.88 | CSF1R (0.52) | CSF1RPDGFRBKITPDGFRAFLT3 | |
| SCHEMBL2676384 | 0.87 | CSF1R (0.45) | CSF1RPDGFRBKITPDGFRAFLT3 | |
| SCHEMBL14396988 | 0.87 | CSF1R (0.52) | CSF1RPDGFRBKITPDGFRAFLT3 | |
| SCHEMBL14396996 | 0.87 | CSF1R (0.52) | CSF1RPDGFRBKITPDGFRAFLT3 | |
| SCHEMBL14396834 | 0.86 | CSF1R (0.65) | CSF1RPDGFRBKITPDGFRAFLT3 | |
| SCHEMBL14396486 | 0.86 | CSF1R (0.59) | CSF1RPDGFRBKITPDGFRAFLT3 | |
| SCHEMBL14396487 | 0.86 | CSF1R (0.67) | CSF1RPDGFRBKITPDGFRAFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010528-B1 | 6-O-SUBSTITUTED BENZOXAZOLE AND BENZOTHIAZOLE COMPOUNDS AND METHODS OF INHIBITING CSF-1R SIGNALING | NOVARTIS AG (CH) | 2017-10-04 | — | — | EP | disclosed |
| WO-2007121484-A2 | 6-O-SUBSTITUTED BENZOXAZOLE AND BENZOTHIAZOLE COMPOUNDS AND METHODS OF INHIBITING CSF-1R SIGNALING | NOVARTIS AG (CH) | 2007-10-25 | — | — | WO | disclosed |