Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 18/20 | 0.43 |
| ▸ | PDGFRA | P16234 | 8/20 | 0.42 |
| ▸ | FLT3 | P36888 | 3/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 6/20 | 0.41 |
| ▸ | KDR | P35968 | 3/20 | 0.41 |
| ▸ | MET | P08581 | 2/20 | 0.41 |
| ▸ | KIT | P10721 | 5/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.40 |
| ▸ | ITK | Q08881 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2676475 | 0.90 | CSF1R (0.42) | CSF1RPDGFRAFLT3PDGFRBKDR | |
| SCHEMBL2676472 | 0.90 | CSF1R (0.42) | CSF1RPDGFRAFLT3PDGFRBKDR | |
| SCHEMBL2676759 | 0.90 | CSF1R (0.42) | CSF1RPDGFRAFLT3PDGFRBKDR | |
| SCHEMBL2677497 | 0.88 | CSF1R (0.41) | CSF1RPDGFRAFLT3PDGFRBKDR | |
| SCHEMBL2677492 | 0.88 | CSF1R (0.41) | CSF1RPDGFRAFLT3PDGFRBKDR | |
| SCHEMBL2677460 | 0.87 | CSF1R (0.43) | CSF1RPDGFRAFLT3PDGFRBKDR | |
| SCHEMBL2677468 | 0.87 | CSF1R (0.43) | CSF1RPDGFRAFLT3PDGFRBKDR | |
| SCHEMBL2676413 | 0.86 | CSF1R (0.43) | CSF1RPDGFRAFLT3PDGFRBKDR | |
| SCHEMBL2678973 | 0.84 | PIK3CD (0.40) | CSF1RPDGFRAFLT3PDGFRBKDR | |
| SCHEMBL2678977 | 0.84 | PIK3CD (0.40) | CSF1RPDGFRAFLT3PDGFRBKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007121484-A2 | 6-O-SUBSTITUTED BENZOXAZOLE AND BENZOTHIAZOLE COMPOUNDS AND METHODS OF INHIBITING CSF-1R SIGNALING | NOVARTIS AG (CH) | 2007-10-25 | — | — | WO | disclosed |