Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 16/20 | 0.52 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.49 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.49 |
| ▸ | KIT | P10721 | 2/20 | 0.49 |
| ▸ | FLT3 | P36888 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.40 |
| ▸ | PI4KA | P42356 | 1/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.40 |
| ▸ | MET | P08581 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14396483 | 0.94 | CSF1R (0.51) | CSF1RPDGFRBPDGFRAKITFLT3 | |
| SCHEMBL19415335 | 0.91 | CSF1R (0.50) | CSF1RPDGFRBPDGFRAKITFLT3 | |
| SCHEMBL14396855 | 0.90 | CSF1R (0.49) | CSF1RPDGFRBPDGFRAKITFLT3 | |
| SCHEMBL14396825 | 0.90 | CSF1R (0.49) | CSF1RPDGFRBPDGFRAKITFLT3 | |
| SCHEMBL14396824 | 0.90 | CSF1R (0.51) | CSF1RPDGFRBPDGFRAKITFLT3 | |
| SCHEMBL14396675 | 0.90 | CSF1R (0.53) | CSF1RPDGFRBPDGFRAKITFLT3 | |
| SCHEMBL2676785 | 0.90 | CSF1R (0.53) | CSF1RPDGFRBPDGFRAKITFLT3 | |
| SCHEMBL14397060 | 0.90 | CSF1R (0.50) | CSF1RPDGFRBPDGFRAKITFLT3 | |
| SCHEMBL2676922 | 0.89 | CSF1R (0.60) | CSF1RPDGFRBPDGFRAKITFLT3 | |
| SCHEMBL2676644 | 0.89 | CSF1R (0.44) | CSF1RPDGFRBPDGFRAKITFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010528-B1 | 6-O-SUBSTITUTED BENZOXAZOLE AND BENZOTHIAZOLE COMPOUNDS AND METHODS OF INHIBITING CSF-1R SIGNALING | NOVARTIS AG (CH) | 2017-10-04 | — | — | EP | disclosed |
| WO-2007121484-A2 | 6-O-SUBSTITUTED BENZOXAZOLE AND BENZOTHIAZOLE COMPOUNDS AND METHODS OF INHIBITING CSF-1R SIGNALING | NOVARTIS AG (CH) | 2007-10-25 | — | — | WO | disclosed |