Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 6/20 | 0.49 |
| ▸ | KIT | P10721 | 5/20 | 0.49 |
| ▸ | IRAK4 | Q9NWZ3 | 5/20 | 0.49 |
| ▸ | AURKA | O14965 | 3/20 | 0.49 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.37 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.37 |
| ▸ | AXL | P30530 | 6/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | INSR | P06213 | 4/20 | 0.36 |
| ▸ | KDR | P35968 | 4/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | TTK | P33981 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12845487 | 0.88 | FLT3 (0.49) | FLT3KITIRAK4AURKAPDGFRB | |
| SCHEMBL12779856 | 0.88 | FLT3 (0.49) | FLT3KITIRAK4AURKAPDGFRB | |
| SCHEMBL12779908 | 0.86 | FLT3 (0.64) | FLT3KITIRAK4AURKAAXL | |
| SCHEMBL12779850 | 0.85 | KIT (0.52) | FLT3KITIRAK4AURKAAXL | |
| SCHEMBL13963811 | 0.83 | FLT3 (0.47) | FLT3KITIRAK4AURKAPDGFRB | |
| SCHEMBL12779962 | 0.77 | FLT3 (0.62) | FLT3KITIRAK4AURKAAXL | |
| SCHEMBL12779937 | 0.77 | MEN1 (0.44) | FLT3KITIRAK4AURKAPDGFRB | |
| SCHEMBL12779942 | 0.75 | KIT (0.59) | FLT3KITIRAK4AURKAMEN1 | |
| SCHEMBL12779955 | 0.74 | FLT3 (0.61) | FLT3KITIRAK4AURKAAXL | |
| SCHEMBL12779965 | 0.73 | KIT (0.59) | FLT3KITIRAK4AURKAAXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7279469-B2 | Diaminotriazoles useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-10-09 | — | — | US | disclosed |