Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 12/20 | 0.54 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.35 |
| ▸ | QPCT | Q16769 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17030627 | 0.96 | CFTR (0.55) | CFTRHTR2APDE4DSCN5AQPCT | |
| SCHEMBL1466503 | 0.89 | CFTR (0.52) | CFTRHTR2APDE4DSCN5AMAPT | |
| SCHEMBL17030579 | 0.85 | CFTR (0.67) | CFTRHTR2APDE4DSCN5AMAPT | |
| SCHEMBL12742012 | 0.82 | CFTR (0.78) | CFTRHTR2APDE4DSCN5ARAB9A | |
| SCHEMBL23506604 | 0.82 | CFTR (0.47) | CFTRHTR2APDE4DSCN5AQPCT | |
| SCHEMBL19753086 | 0.82 | CFTR (0.65) | CFTRHTR2APDE4DSCN5ARAB9A | |
| SCHEMBL12846430 | 0.81 | CFTR (0.52) | CFTRMAPTPOLB | |
| SCHEMBL19085765 | 0.80 | CFTR (0.57) | CFTRHTR2APDE4DSCN5A | |
| SCHEMBL12741360 | 0.79 | CFTR (0.53) | CFTRALDH1A1MAPT | |
| SCHEMBL20194830 | 0.79 | CFTR (0.64) | CFTRHTR2APDE4DSCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007117715-A2 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-10-18 | — | — | WO | disclosed |