Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 11/20 | 0.42 |
| ▸ | PLK4 | O00444 | 3/20 | 0.39 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.39 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.39 |
| ▸ | DAPK3 | O43293 | 3/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.39 |
| ▸ | CHEK2 | O96017 | 3/20 | 0.39 |
| ▸ | PRKCG | P05129 | 3/20 | 0.39 |
| ▸ | CDK1 | P06493 | 3/20 | 0.39 |
| ▸ | PRKACA | P17612 | 3/20 | 0.39 |
| ▸ | CDK2 | P24941 | 3/20 | 0.39 |
| ▸ | MARK3 | P27448 | 3/20 | 0.39 |
| ▸ | AKT2 | P31751 | 3/20 | 0.39 |
| ▸ | FLT4 | P35916 | 3/20 | 0.39 |
| ▸ | CSNK1D | P48730 | 3/20 | 0.39 |
| ▸ | GSK3A | P49840 | 3/20 | 0.39 |
| ▸ | GSK3B | P49841 | 3/20 | 0.39 |
| ▸ | RPS6KA3 | P51812 | 3/20 | 0.39 |
| ▸ | LIMK1 | P53667 | 3/20 | 0.39 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL759864 | 0.92 | MAPKAPK2 (0.42) | MAPKAPK2PLK4MAPK13PDPK1DAPK3 | |
| SCHEMBL759863 | 0.92 | MAPKAPK2 (0.42) | MAPKAPK2PLK4MAPK13PDPK1DAPK3 | |
| SCHEMBL759991 | 0.82 | MAPKAPK2 (0.38) | MAPKAPK2PLK4MAPK13PDPK1DAPK3 | |
| SCHEMBL759992 | 0.82 | MAPKAPK2 (0.38) | MAPKAPK2PLK4MAPK13PDPK1DAPK3 | |
| SCHEMBL757585 | 0.81 | MAPKAPK2 (0.39) | MAPKAPK2PLK4MAPK13PDPK1DAPK3 | |
| SCHEMBL757586 | 0.81 | MAPKAPK2 (0.39) | MAPKAPK2PLK4MAPK13PDPK1DAPK3 | |
| SCHEMBL757768 | 0.78 | MAPKAPK2 (0.45) | MAPKAPK2PLK4MAPK13PDPK1DAPK3 | |
| SCHEMBL757767 | 0.78 | MAPKAPK2 (0.45) | MAPKAPK2PLK4MAPK13PDPK1DAPK3 | |
| SCHEMBL761246 | 0.78 | MAPKAPK2 (0.41) | MAPKAPK2PLK4MAPK13PDPK1DAPK3 | |
| SCHEMBL761245 | 0.78 | MAPKAPK2 (0.41) | MAPKAPK2PLK4MAPK13PDPK1DAPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007117465-A2 | INDAZOLE COMPOUNDS | ABBOTT LABORATORIES (US) | 2007-10-18 | — | — | WO | disclosed |