Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 17/20 | 0.70 |
| ▸ | HDAC8 | Q9BY41 | 15/20 | 0.70 |
| ▸ | HDAC2 | Q92769 | 9/20 | 0.62 |
| ▸ | HDAC4 | P56524 | 8/20 | 0.62 |
| ▸ | HDAC11 | Q96DB2 | 8/20 | 0.62 |
| ▸ | HDAC6 | Q9UBN7 | 8/20 | 0.62 |
| ▸ | HDAC9 | Q9UKV0 | 8/20 | 0.62 |
| ▸ | HDAC5 | Q9UQL6 | 8/20 | 0.62 |
| ▸ | HDAC7 | Q8WUI4 | 7/20 | 0.62 |
| ▸ | HDAC3 | O15379 | 7/20 | 0.62 |
| ▸ | HDAC10 | Q969S8 | 7/20 | 0.62 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | BRD4 | O60885 | 1/20 | 0.60 |
| ▸ | NCOR1 | O75376 | 1/20 | 0.60 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.60 |
| ▸ | EGFR | P00533 | 1/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | LTA4H | P09960 | 1/20 | 0.60 |
| ▸ | NR0B1 | P51843 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8228945 | 0.91 | HDAC1 (0.73) | HDAC1HDAC8HDAC2HDAC4HDAC11 | |
| SCHEMBL10445724 | 0.82 | HDAC1 (1.00) | HDAC1HDAC8HDAC2HDAC4HDAC11 | |
| SCHEMBL3383197 | 0.82 | HDAC1 (1.00) | HDAC1HDAC8HDAC2HDAC4HDAC11 | |
| SCHEMBL1521077 | 0.82 | HDAC1 (1.00) | HDAC1HDAC8HDAC2HDAC4HDAC11 | |
| SCHEMBL1521257 | 0.82 | HDAC1 (1.00) | HDAC1HDAC8HDAC2HDAC4HDAC11 | |
| SCHEMBL1521154 | 0.80 | HDAC1 (1.00) | HDAC1HDAC8HDAC2HDAC4HDAC11 | |
| SCHEMBL27559057 | 0.79 | HDAC1 (0.73) | HDAC1HDAC8HDAC2HDAC4HDAC11 | |
| SCHEMBL15585833 | 0.79 | HDAC1 (0.59) | HDAC1HDAC8HDAC2HDAC4HDAC11 | |
| SCHEMBL28897319 | 0.77 | HDAC1 (0.69) | HDAC1HDAC8HDAC2HDAC4HDAC11 | |
| SCHEMBL1232912 | 0.77 | HDAC6 (1.00) | HDAC1HDAC8HDAC2HDAC4HDAC11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7288567-B2 | Inhibitors of histone deacetylase | METHYLGENE INC. (CA) | 2007-10-30 | — | — | US | disclosed |