SCHEMBL14404270

SCHEMBL14404270

N/C(=N/O)c1ccc(C(=O)Nc2ccc(F)cc2C(=O)Nc2ccc(CI)cn2)cc1

nearest known ligand 0.55

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
F10 P00742 20/20 0.55
KLKB1 P03952 5/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14404490 0.92 F10 (0.46) F10KLKB1
SCHEMBL10146318 0.85 F10 (0.74) F10KLKB1
SCHEMBL12134291 0.85 F10 (0.57) F10KLKB1
SCHEMBL10146267 0.85 F10 (0.57) F10
SCHEMBL14309302 0.85 KDM4E (0.61) F10
SCHEMBL14404272 0.83 F10 (0.58) F10KLKB1
SCHEMBL14404269 0.82 F10 (0.51) F10KLKB1
SCHEMBL14632281 0.81 F10 (0.59) F10
SCHEMBL14404275 0.81 F10 (0.58) F10
SCHEMBL14629887 0.79 F10 (0.65) F10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7285565-B2 Benzamides and related inhibitors of factor Xa MILLENNIUM PHARMACEUTICALS, INC. (US) 2007-10-23 US disclosed