SCHEMBL14404453

SCHEMBL14404453

Cc1ccccc1C1CCNC[C@H]1COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1

nearest known ligand 0.46

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
TACR1 P25103 17/20 0.46
SLC6A4 P31645 10/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL952110 1.00 TACR1 (0.46) TACR1SLC6A4
SCHEMBL952109 1.00 TACR1 (0.46) TACR1SLC6A4
SCHEMBL12601426 1.00 TACR1 (0.46) TACR1SLC6A4
Hydrochloric Acid SCHEMBL956074 0.99 TACR1 (0.46) TACR1SLC6A4
Hydrochloric Acid SCHEMBL956073 0.99 TACR1 (0.46) TACR1SLC6A4
SCHEMBL12672586 0.94 TACR1 (0.41) TACR1SLC6A4
SCHEMBL4006725 0.90 TACR1 (0.46) TACR1SLC6A4
SCHEMBL4967159 0.90 TACR1 (0.46) TACR1SLC6A4
Hydrochloric Acid SCHEMBL4011840 0.89 TACR1 (0.45) TACR1SLC6A4
SCHEMBL12602183 0.85 TACR1 (0.52) TACR1SLC6A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2007113153-A1 PIPERIDINE DERIVATIVES USEFUL AS SEROTONIN TRANSPORTER INHIBITORS AND NEUROKININ-1 RECEPTOR ANTAGONISTS F. HOFFMANN-LA ROCHE AG (CH) 2007-10-11 WO disclosed