Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Methylmalonic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | SLC7A5 | Q01650 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.35 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methylmalonic Acid SCHEMBL27881917 | 0.92 | TP53 (0.57) | TP53SLC7A5TSHRLMNAALDH1A1 | |
| Methylmalonic Acid SCHEMBL27766 | 0.92 | — | — | |
| Methylmalonic Acid SCHEMBL5874913 | 0.88 | — | — | |
| Methylmalonic Acid SCHEMBL11586861 | 0.88 | — | — | |
| Methylmalonic Acid SCHEMBL28384287 | 0.88 | TP53 (0.53) | TP53SLC7A5TSHRLMNAALDH1A1 | |
| Methylmalonic Acid SCHEMBL2572891 | 0.88 | — | — | |
| Methylmalonic Acid SCHEMBL17818678 | 0.88 | — | — | |
| Methylmalonic Acid SCHEMBL10461696 | 0.88 | — | — | |
| Methylmalonic Acid SCHEMBL105829 | 0.88 | — | — | |
| Methylmalonic Acid SCHEMBL29092066 | 0.88 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120059081-A1 | RESINS COMPRISING ACRYLATE GROUPS | BUSCH STEFAN (DE) | 2012-03-08 | — | — | US | disclosed |
| US-4574885-A | ANIONIC POLYMERS ARE USED TO REDUCE THE ADSORPTION OF SURFACTANTS AND CATIONIC POLYMERS IN A FORMATION | PHILLIPS PETROLEUM COMPANY (US) | 1986-03-11 | — | — | US | disclosed |