Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 11/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.64 |
| ▸ | MAPK13 | O15264 | 9/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14409070 | 0.98 | MAPK14 (0.67) | MAPK14CYP2C9MAPK13 | |
| SCHEMBL20448701 | 0.97 | MAPK14 (0.69) | MAPK14CYP2C9MAPK13 | |
| SCHEMBL20448692 | 0.92 | MAPK14 (0.62) | MAPK14CYP2C9MAPK13 | |
| SCHEMBL20448597 | 0.92 | MAPK14 (0.69) | MAPK14CYP2C9MAPK13 | |
| SCHEMBL20448498 | 0.91 | MAPK14 (0.61) | MAPK14CYP2C9MAPK13 | |
| SCHEMBL20448595 | 0.86 | MAPK14 (0.64) | MAPK14CYP2C9MAPK13 | |
| SCHEMBL20460416 | 0.86 | MAPK14 (0.76) | MAPK14CYP2C9MAPK13 | |
| SCHEMBL20460414 | 0.85 | MAPK14 (0.77) | MAPK14CYP2C9MAPK13 | |
| SCHEMBL5123294 | 0.83 | MAPK14 (0.71) | MAPK14CYP2C9MAPK13 | |
| SCHEMBL5417561 | 0.83 | MAPK14 (0.71) | MAPK14CYP2C9MAPK13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7271289-B2 | Biphenylcarboxylic amide derivatives as p38 kinase inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 2007-09-18 | — | — | US | disclosed |
| US-7271289-B2 | Biphenylcarboxylic amide derivatives as p38 kinase inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 2007-09-18 | — | — | US | disclosed |