Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 17/20 | 0.62 |
| ▸ | PGR | P06401 | 10/20 | 0.53 |
| ▸ | NR3C2 | P08235 | 4/20 | 0.53 |
| ▸ | NR3C1 | P04150 | 3/20 | 0.52 |
| ▸ | ESR1 | P03372 | 1/20 | 0.52 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.52 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5232499 | 1.00 | AR (0.62) | ARPGRNR3C2NR3C1ESR1 | |
| SCHEMBL5232494 | 1.00 | AR (0.62) | ARPGRNR3C2NR3C1ESR1 | |
| SCHEMBL5232505 | 1.00 | AR (0.62) | ARPGRNR3C2NR3C1ESR1 | |
| SCHEMBL5232384 | 0.89 | AR (0.71) | ARPGRNR3C2NR3C1ESR1 | |
| SCHEMBL14409284 | 0.89 | AR (0.71) | ARPGRNR3C2NR3C1ESR1 | |
| SCHEMBL5232387 | 0.89 | AR (0.71) | ARPGRNR3C2NR3C1ESR1 | |
| SCHEMBL5232382 | 0.89 | AR (0.71) | ARPGRNR3C2NR3C1ESR1 | |
| SCHEMBL14561713 | 0.87 | AR (0.66) | ARPGRNR3C2NR3C1ESR1 | |
| SCHEMBL5230657 | 0.87 | AR (0.66) | ARPGRNR3C2NR3C1ESR1 | |
| SCHEMBL5230663 | 0.87 | AR (0.66) | ARPGRNR3C2NR3C1ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1439841-B1 | ANDROGEN RECEPTOR MODULATORS AND METHODS OF USE THEREOF | MERCK & CO INC (US) | 2007-09-19 | — | — | EP | disclosed |
| US-7196076-B2 | Androgen receptor modulators and methods of use thereof | MERCK & CO., INC. (US) | 2007-03-27 | — | — | US | disclosed |
| US-7196076-B2 | Androgen receptor modulators and methods of use thereof | MERCK & CO., INC. (US) | 2007-03-27 | — | — | US | disclosed |