SCHEMBL14409882

SCHEMBL14409882

CNC(=O)c1c(C)n(C)c2cc(Oc3ccnc4cc(C(=O)N5CCC[C@H]5CO)sc34)ccc12

nearest known ligand 0.43

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
KDR P35968 20/20 0.43
FLT1 P17948 17/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5241562 1.00 KDR (0.43) KDRFLT1
SCHEMBL5243975 0.93 KDR (0.44) KDRFLT1
SCHEMBL5242752 0.92 KDR (0.46) KDRFLT1
SCHEMBL5242968 0.87 KDR (0.46) KDRFLT1
SCHEMBL14409832 0.86 KDR (0.45) KDRFLT1
SCHEMBL5240496 0.86 KDR (0.45) KDRFLT1
SCHEMBL5241433 0.86 KDR (0.43) KDRFLT1
SCHEMBL14409887 0.84 KDR (0.47) KDRFLT1
SCHEMBL5244123 0.84 KDR (0.47) KDRFLT1
SCHEMBL5240135 0.84 KDR (0.43) KDRFLT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1515975-B1 BENZOFUSED HETEROARYL AMIDE DERIVATIVES OF THIENOPYRIDINES USEFUL AS THERAPEUTIC AGENTS, PHARMACEUTICAL COMPOSITIONS INCLUDING THE SAME, AND METHODS FOR THEIR USE PFIZER (US) 2007-09-19 EP disclosed