Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 5/20 | 0.54 |
| ▸ | ABL1 | P00519 | 1/20 | 0.49 |
| ▸ | KIT | P10721 | 3/20 | 0.45 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 3/20 | 0.42 |
| ▸ | BTK | Q06187 | 1/20 | 0.42 |
| ▸ | ITK | Q08881 | 1/20 | 0.42 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.40 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.40 |
| ▸ | TNIK | Q9UKE5 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12763021 | 0.97 | MAP4K1 (0.56) | MAP4K1ABL1KITCAMKK2PARP1 | |
| SCHEMBL14209767 | 0.92 | MAP4K1 (0.55) | MAP4K1ABL1KITCAMKK2AAK1 | |
| SCHEMBL12763023 | 0.91 | MAP4K1 (0.59) | MAP4K1ABL1KITCAMKK2AAK1 | |
| SCHEMBL13341911 | 0.90 | MAP4K1 (0.53) | MAP4K1ABL1KITCAMKK2PARP1 | |
| SCHEMBL12763589 | 0.89 | MAP4K1 (0.52) | MAP4K1ABL1KITCAMKK2BTK | |
| SCHEMBL13342297 | 0.89 | MAP4K1 (0.57) | MAP4K1ABL1KITCAMKK2BTK | |
| SCHEMBL12763020 | 0.89 | MAP4K1 (0.56) | MAP4K1ABL1KITCAMKK2AAK1 | |
| SCHEMBL12763565 | 0.89 | MAP4K1 (0.67) | MAP4K1ABL1KITCAMKK2AAK1 | |
| SCHEMBL13342299 | 0.89 | MAP4K1 (0.56) | MAP4K1ABL1KITCAMKK2AAK1 | |
| SCHEMBL13342272 | 0.88 | MAP4K1 (0.54) | MAP4K1ABL1KITCAMKK2BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007106236-A2 | PYRROLO-PYRIDINE KINASE MODULATORS | SGX PHARMACEUTICALS, INC. (US) | 2007-09-20 | — | — | WO | disclosed |