SCHEMBL14414973

SCHEMBL14414973

CCOC(=O)C(C)(C)Oc1c(C)cc(CN(Cc2ncco2)Cc2nnc(-c3cccs3)o2)cc1C

nearest known ligand 0.41

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
HPGD P15428 7/20 0.41
MAPT P10636 2/20 0.41
TSHR P16473 2/20 0.41
PPARG P37231 1/20 0.39
PPARA Q07869 1/20 0.39
ALDH1A1 P00352 8/20 0.37
KDM4E B2RXH2 5/20 0.36
RAB9A P51151 4/20 0.36
NPC1 O15118 3/20 0.36
SMN1; SMN2 Q16637 3/20 0.36
POLB P06746 2/20 0.36
NPSR1 Q6W5P4 1/20 0.36
HSD17B10 Q99714 2/20 0.35
MAPK1 P28482 1/20 0.35
LMNA P02545 1/20 0.34
MEN1 O00255 1/20 0.34
KMT2A Q03164 1/20 0.34
TP53 P04637 3/20 0.34
L3MBTL1 Q9Y468 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14414974 0.91 PPARA (0.48) HPGDMAPTTSHRPPARGPPARA
SCHEMBL5476286 0.87 PPARA (0.50) HPGDMAPTPPARGPPARAALDH1A1
SCHEMBL5477561 0.85 MAPT (0.47) MAPTTSHRPPARGPPARAALDH1A1
SCHEMBL5482064 0.82 HPGD (0.38) HPGDMAPTTSHRPPARGPPARA
SCHEMBL5472024 0.80 PPARA (0.39) TSHRPPARGPPARA
SCHEMBL5487326 0.79 PPARA (0.59) HPGDPPARGPPARAALDH1A1SMN1; SMN2
SCHEMBL14414922 0.79 POLB (0.42) HPGDMAPTPPARGPPARAALDH1A1
SCHEMBL5472016 0.78 PPARG (0.51) PPARGPPARAALDH1A1KDM4ELMNA
SCHEMBL14414971 0.78 PPARA (0.46) PPARGPPARA
SCHEMBL14414923 0.78 PPARA (0.33) HPGDMAPTPPARGPPARAALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20070208021-A1 Phenoxyacetic Acid Derivatives and Drug Comprising The Same DAIICHI PHARMACEUTICAL CO., LTD. 2007-09-06 US disclosed
US-20070208021-A1 Phenoxyacetic Acid Derivatives and Drug Comprising The Same DAIICHI PHARMACEUTICAL CO., LTD. 2007-09-06 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070208021-A1 Phenoxyacetic Acid Derivatives and Drug Comprising The Same PPARA, PPARG, PPARD HPGD 976/4885MAPT 3974/4885TSHR 176/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.