Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 5/20 | 0.86 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.86 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.86 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.86 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.86 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.86 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.86 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.86 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.86 |
| ▸ | HDAC9 | Q9UKV0 | 5/20 | 0.86 |
| ▸ | HDAC5 | Q9UQL6 | 5/20 | 0.86 |
| ▸ | ABL1 | P00519 | 12/20 | 0.83 |
| ▸ | SRC | P12931 | 9/20 | 0.83 |
| ▸ | LCK | P06239 | 5/20 | 0.83 |
| ▸ | EGFR | P00533 | 3/20 | 0.83 |
| ▸ | FYN | P06241 | 3/20 | 0.83 |
| ▸ | YES1 | P07947 | 3/20 | 0.83 |
| ▸ | LYN | P07948 | 3/20 | 0.83 |
| ▸ | HCK | P08631 | 3/20 | 0.83 |
| ▸ | KIT | P10721 | 3/20 | 0.83 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29750253 | 0.94 | HDAC3 (0.86) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL1704971 | 0.94 | HDAC3 (0.86) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| Hydrochloric Acid SCHEMBL29817345 | 0.93 | HDAC3 (0.85) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL13626293 | 0.93 | ABL1 (0.89) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL1146496 | 0.92 | HDAC3 (1.00) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL19362612 | 0.92 | ABL1 (0.85) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL28914780 | 0.92 | ABL1 (0.88) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL16569731 | 0.92 | ABL1 (0.84) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL1147166 | 0.91 | HDAC3 (0.81) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL13164781 | 0.91 | ABL1 (0.88) | HDAC3HDAC4HDAC1HDAC7HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070219370-A1 | PROCESS FOR PREPARING N-(2-CHLORO-6-METHYLPHENYL)-2-[[6-[4-(2-HYDROXYETHYL)-1-PIPERAZINYL]-2-METHYL-4-PYRIMIDINYL]AMINO] -5-THIAZOLECARBOXAMIDE AND RELATED METABOLITES THEREOF | BRISTOL-MYERS SQUIBB COMPANY | 2007-09-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070219370-A1 | PROCESS FOR PREPARING N-(2-CHLORO-6-METHYLPHENYL)-2-[[6-[4-(2-HYDROXYETHYL)-1-PIPERAZINYL]-2-METHYL-4-PYRIMIDINYL]AMINO] -5-THIAZOLECARBOXAMIDE AND RELATED METABOLITES THEREOF | UGT1A6, PAH, CYP2B6 | HDAC3 921/4885HDAC4 982/4885HDAC1 1279/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.