Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C5AR1 | P21730 | 1/20 | 0.49 |
| ▸ | CTSL | P07711 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | F2R | P25116 | 5/20 | 0.37 |
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL649999 | 0.95 | C5AR1 (0.56) | C5AR1CTSLSMN1; SMN2TDP1PPARG | |
| SCHEMBL649149 | 0.86 | C5AR1 (0.64) | C5AR1CTSLKDM4ESMN1; SMN2TDP1 | |
| SCHEMBL650388 | 0.84 | C5AR1 (0.65) | C5AR1CTSLKDM4EGFERSMN1; SMN2 | |
| SCHEMBL1912864 | 0.83 | C5AR1 (0.63) | C5AR1KDM4EGFERSMN1; SMN2TDP1 | |
| SCHEMBL649490 | 0.82 | C5AR1 (0.62) | C5AR1KDM4EGFERSMN1; SMN2TDP1 | |
| SCHEMBL5135945 | 0.81 | C5AR1 (0.57) | C5AR1CTSLKDM4ESMN1; SMN2TDP1 | |
| SCHEMBL652877 | 0.80 | C5AR1 (0.66) | C5AR1KDM4EGFERSMN1; SMN2TDP1 | |
| SCHEMBL651679 | 0.80 | C5AR1 (0.58) | C5AR1KDM4EGFERSMN1; SMN2TDP1 | |
| SCHEMBL648390 | 0.79 | C5AR1 (0.54) | C5AR1KDM4ESMN1; SMN2TDP1PPARG | |
| SCHEMBL651099 | 0.79 | C5AR1 (0.58) | C5AR1SMN1; SMN2TDP1TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070208048-A1 | New Aryl Imidazoles and Related Compounds as C5a Receptor Modulators | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2007-09-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070208048-A1 | New Aryl Imidazoles and Related Compounds as C5a Receptor Modulators | C3AR1, C5AR1, C5AR2 | C5AR1 2/4885CTSL 3062/4885KDM4E 2551/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.