Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 5/20 | 0.49 |
| ▸ | GRM5 | P41594 | 5/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.41 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28593056 | 0.83 | GRM5 (0.56) | FFAR1GRM5CYP1A2CYP3A4FFAR4 | |
| SCHEMBL1232576 | 0.80 | FFAR1 (0.58) | FFAR1FFAR4ALDH1A1MEN1THRB | |
| SCHEMBL1232570 | 0.80 | FFAR1 (0.58) | FFAR1FFAR4ALDH1A1MEN1THRB | |
| SCHEMBL3887442 | 0.80 | FFAR1 (0.58) | FFAR1FFAR4ALDH1A1MEN1THRB | |
| SCHEMBL138849 | 0.77 | GRM5 (0.50) | FFAR1GRM5CYP1A2CYP3A4FFAR4 | |
| SCHEMBL28580421 | 0.75 | GRM5 (0.45) | FFAR1GRM5CYP1A2CYP3A4FFAR4 | |
| SCHEMBL5380220 | 0.75 | FFAR1 (0.54) | FFAR1GRM5FFAR4EGLN1 | |
| SCHEMBL1662176 | 0.75 | CSNK2A1 (0.47) | MAPTKMT2A | |
| SCHEMBL1662174 | 0.75 | CSNK2A1 (0.47) | MAPTKMT2A | |
| SCHEMBL8296811 | 0.75 | HDAC8 (0.60) | ALDH1A1MEN1THRBKMT2AHDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE39850-E1 | Aryl amide, -sulfonamide, or -urea derivatives; antiproliferative, antitumor, anticarcinogenic, and/or antimetastasis agents | METHYLGENE, INC. (CA) | 2007-09-18 | — | — | US | disclosed |