Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 2/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.46 |
| ▸ | CCR5 | P51681 | 1/20 | 0.46 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | HPGD | P15428 | 4/20 | 0.37 |
| ▸ | GAA | P10253 | 3/20 | 0.37 |
| ▸ | CASP1 | P29466 | 3/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | AVPR1A | P37288 | 3/20 | 0.34 |
| ▸ | HRH1 | P35367 | 5/20 | 0.34 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | SLC6A15 | Q9H2J7 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15478312 | 0.92 | CCR1 (0.48) | CCR1CHRM2CCR5S1PR5AVPR1A | |
| SCHEMBL13824432 | 0.92 | CCR1 (0.48) | CCR1CHRM2CCR5S1PR5AVPR1A | |
| SCHEMBL16312643 | 0.90 | CCR1 (0.48) | CCR1CHRM2CCR5S1PR5AVPR1A | |
| SCHEMBL12121845 | 0.88 | CCR1 (0.51) | CCR1CHRM2CCR5S1PR5HRH1 | |
| SCHEMBL14579627 | 0.88 | CCR1 (0.49) | CCR1CHRM2CCR5S1PR5HRH1 | |
| SCHEMBL10287557 | 0.88 | CCR1 (0.49) | CCR1CHRM2CCR5S1PR5KDM4E | |
| SCHEMBL13824434 | 0.88 | CCR1 (0.48) | CCR1CHRM2CCR5S1PR5AVPR1A | |
| SCHEMBL14420122 | 0.88 | CCR1 (0.49) | CCR1CHRM2CCR5S1PR5HRH1 | |
| SCHEMBL13824440 | 0.87 | CCR1 (0.52) | CCR1CHRM2CCR5S1PR5AVPR1A | |
| SCHEMBL7208051 | 0.86 | CCR1 (0.56) | CCR1CHRM2CCR5KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7271176-B2 | Chemokine receptor antagonists and methods of use thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2007-09-18 | — | — | US | disclosed |