Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 4/20 | 0.59 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.49 |
| ▸ | CCR5 | P51681 | 1/20 | 0.49 |
| ▸ | DRD2 | P14416 | 6/20 | 0.42 |
| ▸ | DRD3 | P35462 | 3/20 | 0.42 |
| ▸ | HRH1 | P35367 | 2/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | DRD1 | P21728 | 1/20 | 0.42 |
| ▸ | DRD5 | P21918 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13824393 | 0.94 | CCR1 (0.59) | CCR1CHRM2CCR5DRD2DRD3 | |
| SCHEMBL7211475 | 0.93 | CCR1 (0.59) | CCR1CHRM2CCR5DRD2DRD3 | |
| SCHEMBL7211479 | 0.93 | CCR1 (0.59) | CCR1CHRM2CCR5DRD2DRD3 | |
| SCHEMBL14419951 | 0.93 | CCR1 (0.59) | CCR1CHRM2CCR5DRD2DRD3 | |
| SCHEMBL10288251 | 0.93 | CCR1 (0.60) | CCR1CHRM2CCR5DRD2DRD3 | |
| SCHEMBL13620889 | 0.93 | CCR1 (0.60) | CCR1CHRM2CCR5DRD2DRD3 | |
| SCHEMBL10287610 | 0.93 | CCR1 (0.60) | CCR1CHRM2CCR5DRD2DRD3 | |
| SCHEMBL14419984 | 0.92 | CCR1 (0.57) | CCR1CHRM2CCR5DRD2DRD3 | |
| SCHEMBL7210692 | 0.92 | CCR1 (0.58) | CCR1CHRM2CCR5DRD2DRD3 | |
| SCHEMBL7206227 | 0.92 | CCR1 (0.58) | CCR1CHRM2CCR5DRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7271176-B2 | Chemokine receptor antagonists and methods of use thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2007-09-18 | — | — | US | disclosed |