Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 2/20 | 0.55 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.55 |
| ▸ | CCR5 | P51681 | 1/20 | 0.55 |
| ▸ | DRD2 | P14416 | 2/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | CCR2 | P41597 | 6/20 | 0.34 |
| ▸ | HRH1 | P35367 | 3/20 | 0.34 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | CX3CR1 | P49238 | 1/20 | 0.33 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14419987 | 0.89 | CCR1 (0.53) | CCR1CHRM2CCR5DRD2DRD3 | |
| SCHEMBL14419953 | 0.89 | CCR1 (0.56) | CCR1CHRM2CCR5DRD2DRD3 | |
| SCHEMBL12121935 | 0.88 | CCR1 (0.52) | CCR1CHRM2CCR5DRD2DRD3 | |
| SCHEMBL13620898 | 0.87 | CCR1 (0.71) | CCR1CHRM2CCR5HRH1 | |
| SCHEMBL7212910 | 0.86 | CCR1 (0.54) | CCR1CHRM2CCR5DRD2DRD3 | |
| SCHEMBL7212913 | 0.86 | CCR1 (0.54) | CCR1CHRM2CCR5DRD2DRD3 | |
| SCHEMBL16312680 | 0.86 | CCR1 (0.52) | CCR1CHRM2CCR5DRD2DRD3 | |
| SCHEMBL10288233 | 0.86 | CCR1 (0.53) | CCR1CHRM2CCR5DRD2DRD3 | |
| SCHEMBL14579629 | 0.85 | CCR1 (0.62) | CCR1CHRM2CCR5DRD2HRH1 | |
| SCHEMBL13620879 | 0.85 | CCR1 (0.56) | CCR1CHRM2CCR5DRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7271176-B2 | Chemokine receptor antagonists and methods of use thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2007-09-18 | — | — | US | disclosed |