Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 6/20 | 0.60 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.54 |
| ▸ | CCR5 | P51681 | 1/20 | 0.54 |
| ▸ | HRH1 | P35367 | 2/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 3/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10287507 | 0.93 | CCR1 (0.57) | CCR1CHRM2CCR5HRH1OPRM1 | |
| SCHEMBL13824233 | 0.91 | CCR1 (0.60) | CCR1CHRM2CCR5HRH1OPRM1 | |
| SCHEMBL12121902 | 0.89 | CCR1 (0.62) | CCR1CHRM2CCR5HRH1DRD2 | |
| SCHEMBL14419959 | 0.89 | CCR1 (0.66) | CCR1CHRM2CCR5HRH1OPRM1 | |
| SCHEMBL13824477 | 0.89 | CCR1 (0.66) | CCR1CHRM2CCR5HRH1OPRM1 | |
| SCHEMBL12301360 | 0.88 | CCR1 (0.66) | CCR1CHRM2CCR5HRH1DRD2 | |
| SCHEMBL12121850 | 0.88 | CCR1 (0.66) | CCR1CHRM2CCR5HRH1DRD2 | |
| SCHEMBL14420164 | 0.88 | CCR1 (0.60) | CCR1CHRM2CCR5HRH1OPRM1 | |
| SCHEMBL10288257 | 0.88 | CCR1 (0.60) | CCR1CHRM2CCR5HRH1OPRM1 | |
| SCHEMBL10287872 | 0.88 | CCR1 (0.60) | CCR1CHRM2CCR5HRH1OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7271176-B2 | Chemokine receptor antagonists and methods of use thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2007-09-18 | — | — | US | disclosed |