Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 2/20 | 0.62 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.48 |
| ▸ | CCR5 | P51681 | 1/20 | 0.48 |
| ▸ | HRH1 | P35367 | 5/20 | 0.32 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.32 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.32 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.32 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.30 |
| ▸ | HTR2B | P41595 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL656051 | 1.00 | CCR1 (0.62) | CCR1CHRM2CCR5HRH1ADRA1D | |
| SCHEMBL656050 | 1.00 | CCR1 (0.62) | CCR1CHRM2CCR5HRH1ADRA1D | |
| SCHEMBL652819 | 0.91 | CCR1 (0.60) | CCR1CHRM2CCR5HRH1ADRA1D | |
| SCHEMBL654801 | 0.91 | CCR1 (0.60) | CCR1CHRM2CCR5HRH1ADRA1D | |
| SCHEMBL10288003 | 0.91 | CCR1 (0.60) | CCR1CHRM2CCR5HRH1ADRA1D | |
| SCHEMBL653479 | 0.91 | CCR1 (0.60) | CCR1CHRM2CCR5HRH1ADRA1D | |
| SCHEMBL653480 | 0.91 | CCR1 (0.60) | CCR1CHRM2CCR5HRH1ADRA1D | |
| SCHEMBL15478339 | 0.91 | CCR1 (0.60) | CCR1CHRM2CCR5HRH1ADRA1D | |
| SCHEMBL656199 | 0.91 | CCR1 (0.62) | CCR1CHRM2CCR5HRH1ADRA1D | |
| SCHEMBL656198 | 0.91 | CCR1 (0.62) | CCR1CHRM2CCR5HRH1ADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8653096-B2 | Chemokine receptor antagonists and methods of use thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2014-02-18 | — | — | US | disclosed |
| US-7271176-B2 | Chemokine receptor antagonists and methods of use thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2007-09-18 | — | — | US | disclosed |