Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 2/20 | 0.75 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.53 |
| ▸ | CCR5 | P51681 | 1/20 | 0.53 |
| ▸ | HRH1 | P35367 | 6/20 | 0.37 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.36 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.36 |
| ▸ | LTA4H | P09960 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.34 |
| ▸ | TBXA2R | P21731 | 3/20 | 0.33 |
| ▸ | TET3 | O43151 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | FBXL19 | Q6PCT2 | 1/20 | 0.33 |
| ▸ | CXXC5 | Q7LFL8 | 1/20 | 0.33 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.33 |
| ▸ | CXXC4 | Q9H2H0 | 1/20 | 0.33 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL652001 | 1.00 | CCR1 (0.75) | CCR1CHRM2CCR5HRH1ADRA1D | |
| SCHEMBL652000 | 1.00 | CCR1 (0.75) | CCR1CHRM2CCR5HRH1ADRA1D | |
| SCHEMBL651597 | 0.94 | CCR1 (0.75) | CCR1CHRM2CCR5HRH1ADRA1D | |
| SCHEMBL651598 | 0.94 | CCR1 (0.75) | CCR1CHRM2CCR5HRH1ADRA1D | |
| SCHEMBL14579807 | 0.94 | CCR1 (0.75) | CCR1CHRM2CCR5HRH1ADRA1D | |
| SCHEMBL654733 | 0.94 | CCR1 (0.74) | CCR1CHRM2CCR5HRH1ADRA1D | |
| SCHEMBL654732 | 0.94 | CCR1 (0.74) | CCR1CHRM2CCR5HRH1ADRA1D | |
| SCHEMBL656288 | 0.92 | CCR1 (0.72) | CCR1CHRM2CCR5HRH1ADRA1D | |
| SCHEMBL14420193 | 0.92 | CCR1 (0.72) | CCR1CHRM2CCR5HRH1ADRA1D | |
| SCHEMBL656289 | 0.92 | CCR1 (0.72) | CCR1CHRM2CCR5HRH1ADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7271176-B2 | Chemokine receptor antagonists and methods of use thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2007-09-18 | — | — | US | disclosed |