Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 2/20 | 0.73 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.52 |
| ▸ | CCR5 | P51681 | 1/20 | 0.52 |
| ▸ | HRH1 | P35367 | 3/20 | 0.31 |
| ▸ | HTR2B | P41595 | 1/20 | 0.31 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.31 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.30 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.30 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL654483 | 1.00 | CCR1 (0.73) | CCR1CHRM2CCR5HRH1HTR2B | |
| SCHEMBL654482 | 1.00 | CCR1 (0.73) | CCR1CHRM2CCR5HRH1HTR2B | |
| SCHEMBL655091 | 0.94 | CCR1 (0.72) | CCR1CHRM2CCR5HRH1HTR2B | |
| SCHEMBL655092 | 0.94 | CCR1 (0.72) | CCR1CHRM2CCR5HRH1HTR2B | |
| SCHEMBL656406 | 0.92 | CCR1 (0.75) | CCR1CHRM2CCR5HRH1HTR2B | |
| SCHEMBL656190 | 0.92 | CCR1 (0.75) | CCR1CHRM2CCR5HRH1HTR2B | |
| SCHEMBL656189 | 0.92 | CCR1 (0.75) | CCR1CHRM2CCR5HRH1HTR2B | |
| SCHEMBL656407 | 0.92 | CCR1 (0.75) | CCR1CHRM2CCR5HRH1HTR2B | |
| SCHEMBL10288000 | 0.90 | CCR1 (0.71) | CCR1CHRM2CCR5MDM2 | |
| SCHEMBL655176 | 0.90 | CCR1 (0.71) | CCR1CHRM2CCR5MDM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7271176-B2 | Chemokine receptor antagonists and methods of use thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2007-09-18 | — | — | US | disclosed |