Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 13/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | AHR | P35869 | 1/20 | 0.47 |
| ▸ | PTGES | O14684 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | ATF1 | P18846 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14422249 | 0.79 | MAPT (0.58) | TRPV1ALDH1A1LMNAHTTAHR | |
| SCHEMBL14422258 | 0.73 | MAPT (0.54) | TRPV1LMNAAHRALOX5 | |
| SCHEMBL16761992 | 0.71 | TRPV1 (0.67) | TRPV1NPC1RAB9A | |
| SCHEMBL5221352 | 0.71 | TRPV1 (0.44) | TRPV1 | |
| SCHEMBL14422192 | 0.70 | MAPT (0.58) | TRPV1LMNAAHRPTGESSMN1; SMN2 | |
| SCHEMBL25257907 | 0.70 | KCNQ3 (0.54) | TRPV1LMNAAHRSMN1; SMN2NPC1 | |
| SCHEMBL30184161 | 0.70 | KCNQ3 (0.54) | TRPV1LMNAAHRSMN1; SMN2NPC1 | |
| SCHEMBL14427857 | 0.70 | MAPT (0.50) | TRPV1LMNAAHRPTGESALOX5 | |
| SCHEMBL17448401 | 0.70 | POLB (0.64) | TRPV1ALDH1A1LMNAAHRSMN1; SMN2 | |
| SCHEMBL17152729 | 0.70 | SMN1; SMN2 (0.56) | TRPV1LMNAAHRSMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7265138-B2 | Vanilloid receptor ligands and their use in treatments | AMGEN INC. (US) | 2007-09-04 | — | — | US | disclosed |
| US-7265138-B2 | Vanilloid receptor ligands and their use in treatments | AMGEN INC. (US) | 2007-09-04 | — | — | US | disclosed |
| EP-1818333-A1 | Vanilloid receptor ligands and their use in treatments | Amgen Inc. (US) | 2007-08-15 | — | — | EP | disclosed |