Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 15/20 | 1.00 |
| ▸ | FLT3 | P36888 | 2/20 | 0.56 |
| ▸ | GSK3B | P49841 | 2/20 | 0.56 |
| ▸ | JAK2 | O60674 | 1/20 | 0.56 |
| ▸ | CDK2 | P24941 | 1/20 | 0.56 |
| ▸ | JAK3 | P52333 | 1/20 | 0.56 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.56 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.56 |
| ▸ | AURKA | O14965 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14422647 | 0.86 | PIM1 (1.00) | PIM1FLT3GSK3BJAK2CDK2 | |
| SCHEMBL14422627 | 0.86 | PIM1 (1.00) | PIM1FLT3GSK3BJAK2CDK2 | |
| SCHEMBL14422665 | 0.85 | PIM1 (1.00) | PIM1FLT3GSK3BJAK2CDK2 | |
| SCHEMBL14422680 | 0.83 | PIM1 (0.71) | PIM1FLT3GSK3BJAK2CDK2 | |
| SCHEMBL14422676 | 0.83 | PIM1 (1.00) | PIM1FLT3GSK3BJAK2CDK2 | |
| SCHEMBL4783817 | 0.80 | PIM1 (0.87) | PIM1FLT3GSK3BJAK2CDK2 | |
| SCHEMBL14422761 | 0.79 | PIM1 (0.65) | PIM1FLT3GSK3BJAK2CDK2 | |
| SCHEMBL14422661 | 0.79 | PIM1 (0.68) | PIM1FLT3GSK3BJAK2CDK2 | |
| SCHEMBL14422660 | 0.77 | PIM1 (1.00) | PIM1FLT3GSK3BJAK2CDK2 | |
| SCHEMBL14422681 | 0.74 | PIM1 (1.00) | PIM1FLT3GSK3BJAK2CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7268136-B2 | Compositions useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-09-11 | — | — | US | disclosed |
| US-7268136-B2 | Compositions useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-09-11 | — | — | US | disclosed |