Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 7/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | STAT3 | P40763 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | STAT1 | P42224 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2655114 | 0.90 | GCK (0.55) | GCKMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL2655116 | 0.90 | GCK (0.55) | GCKMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL2653423 | 0.87 | GCK (0.53) | GCKMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL2653417 | 0.87 | GCK (0.53) | GCKMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL2653822 | 0.87 | GCK (0.52) | GCKMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL2653827 | 0.87 | GCK (0.52) | GCKMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL14423913 | 0.85 | GCK (0.51) | GCKMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL2655132 | 0.81 | GCK (0.56) | GCKMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL2655134 | 0.81 | GCK (0.56) | GCKMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL2654899 | 0.80 | GCK (0.55) | GCKMEN1KMT2AALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7262196-B2 | Tri(cyclo) substituted amide glucokinase activator compounds | PROSIDION LIMITED (GB) | 2007-08-28 | — | — | US | disclosed |
| US-7262196-B2 | Tri(cyclo) substituted amide glucokinase activator compounds | PROSIDION LIMITED (GB) | 2007-08-28 | — | — | US | disclosed |