Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | MET | P08581 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | LTK | P29376 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 9/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | NPY1R | P25929 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12046438 | 0.91 | CHEK1 (0.42) | MEN1KMT2AGAAHSP90AA1HSP90AB1 | |
| SCHEMBL1148606 | 0.90 | MEN1 (0.44) | MEN1KMT2AGAAHSP90AA1HSP90AB1 | |
| SCHEMBL12046461 | 0.81 | FGFR1 (0.35) | HSP90AA1HSP90AB1MAPTCHEK1LMNA | |
| SCHEMBL1344666 | 0.80 | GRK6 (0.43) | MEN1KMT2AGAAHSP90AA1HSP90AB1 | |
| SCHEMBL1148734 | 0.80 | KMT2A (0.45) | MEN1KMT2AGAAHSP90AA1HSP90AB1 | |
| SCHEMBL12046414 | 0.80 | MEN1 (0.45) | MEN1KMT2AGAAHSP90AA1HSP90AB1 | |
| SCHEMBL1147887 | 0.79 | MEN1 (0.44) | MEN1KMT2AGAAHSP90AA1HSP90AB1 | |
| SCHEMBL1148482 | 0.79 | MEN1 (0.44) | MEN1KMT2AGAAHSP90AA1HSP90AB1 | |
| SCHEMBL1148627 | 0.78 | KMT2A (0.45) | MEN1KMT2AGAAHSP90AA1HSP90AB1 | |
| SCHEMBL12046424 | 0.78 | MEN1 (0.45) | MEN1KMT2AGAAHSP90AA1HSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070191445-A1 | heat shock protein 90 inhibitors; antiproliferative agents; angiogenesis inhibitors | LSI FINANCING LLC, AS ADMINISTRATIVE AGENT | 2007-08-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070191445-A1 | heat shock protein 90 inhibitors; antiproliferative agents; angiogenesis inhibitors | HSP90AB1, HSP90AA1, HSP90AB2P | MEN1 4130/4885KMT2A 4191/4885GAA 2152/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.