Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NQO2 | P16083 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.34 |
| ▸ | RAD52 | P43351 | 1/20 | 0.33 |
| ▸ | RPS6KB2 | Q9UBS0 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12134963 | 0.87 | KDM4E (0.43) | NQO2CYP1A2KDM4EMEN1KMT2A | |
| SCHEMBL14419032 | 0.82 | NQO2 (0.54) | NQO2CYP1A2CYP2A6KDM4EMEN1 | |
| SCHEMBL14425574 | 0.82 | NQO2 (0.54) | NQO2CYP1A2CYP2A6KDM4EMEN1 | |
| SCHEMBL14425614 | 0.82 | CLK1 (0.39) | MEN1KMT2ANPC1RAB9A | |
| SCHEMBL14425615 | 0.82 | CLK1 (0.39) | MEN1KMT2ANPC1RAB9A | |
| SCHEMBL14531950 | 0.76 | — | — | |
| SCHEMBL14127894 | 0.73 | KDM4E (0.41) | NQO2CYP1A2KDM4EMEN1KMT2A | |
| SCHEMBL13712728 | 0.72 | LATS1 (0.33) | CYP2A6MEN1KMT2ANPC1RAB9A | |
| SCHEMBL12134730 | 0.72 | LATS1 (0.33) | CYP2A6MEN1KMT2ANPC1RAB9A | |
| SCHEMBL14425562 | 0.71 | MAPT (0.38) | KDM4EALDH1A1HPGDMAPTRAD52 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7273869-B2 | Inhibitors of Akt activity | MERCK & CO., INC. (US) | 2007-09-25 | — | — | US | disclosed |