Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 11/20 | 0.76 |
| ▸ | KMT2A | Q03164 | 10/20 | 0.76 |
| ▸ | MEN1 | O00255 | 8/20 | 0.76 |
| ▸ | MAPT | P10636 | 7/20 | 0.76 |
| ▸ | POLB | P06746 | 7/20 | 0.76 |
| ▸ | PKM | P14618 | 6/20 | 0.76 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.76 |
| ▸ | APEX1 | P27695 | 5/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.76 |
| ▸ | CTDSP1 | Q9GZU7 | 4/20 | 0.76 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.76 |
| ▸ | PTGES | O14684 | 1/20 | 0.76 |
| ▸ | BLM | P54132 | 7/20 | 0.74 |
| ▸ | ITGB2 | P05107 | 2/20 | 0.73 |
| ▸ | ITGAM | P11215 | 2/20 | 0.73 |
| ▸ | HPGD | P15428 | 2/20 | 0.72 |
| ▸ | RECQL | P46063 | 2/20 | 0.72 |
| ▸ | ESR1 | P03372 | 1/20 | 0.72 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.72 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30657779 | 1.00 | TDP1 (0.76) | TDP1KMT2AMEN1MAPTPOLB | |
| SCHEMBL29901208 | 0.91 | LCK (0.86) | TDP1KMT2AMEN1MAPTPOLB | |
| SCHEMBL14426579 | 0.91 | LCK (0.86) | TDP1KMT2AMEN1MAPTPOLB | |
| SCHEMBL14426591 | 0.86 | ITGB2 (0.78) | TDP1KMT2AMEN1MAPTPOLB | |
| SCHEMBL29439068 | 0.86 | ITGB2 (0.78) | TDP1KMT2AMEN1MAPTPOLB | |
| SCHEMBL14291886 | 0.86 | ITGB2 (0.78) | TDP1KMT2AMEN1MAPTPOLB | |
| SCHEMBL14426593 | 0.85 | KMT2A (1.00) | TDP1KMT2AMEN1MAPTPOLB | |
| SCHEMBL46257 | 0.84 | ITGB2 (1.00) | TDP1KMT2AMEN1MAPTPOLB | |
| SCHEMBL14426456 | 0.84 | LCK (1.00) | TDP1KMT2AMEN1MAPTPOLB | |
| SCHEMBL14291479 | 0.82 | KMT2A (0.80) | TDP1KMT2AMEN1MAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070196395-A1 | Immunomodulatory compounds that target and inhibit the py'binding site of tyrosene kinase p56 lck sh2 domain | UNIVERSITY OF MARYLAND, BALTIMORE | 2007-08-23 | — | — | US | disclosed |
| US-20070196395-A1 | Immunomodulatory compounds that target and inhibit the py'binding site of tyrosene kinase p56 lck sh2 domain | UNIVERSITY OF MARYLAND, BALTIMORE | 2007-08-23 | — | — | US | disclosed |
| US-20070099970-A1 | Immunomodulatory compounds that target and inhibit the pY'binding site of tyrosene kinase p56 LCK SH2 domain | UNIVERSITY OF MARYLAND, BALTIMORE | 2007-05-03 | — | — | US | disclosed |
| US-20070099970-A1 | Immunomodulatory compounds that target and inhibit the pY'binding site of tyrosene kinase p56 LCK SH2 domain | UNIVERSITY OF MARYLAND, BALTIMORE | 2007-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070099970-A1 | Immunomodulatory compounds that target and inhibit the pY'binding site of tyrosene kinase p56 LCK SH2 domain | LCK, PTPN6, PTPN22 | TDP1 1445/4885KMT2A 2476/4885MEN1 4192/4885 |
| US-20070196395-A1 | Immunomodulatory compounds that target and inhibit the py'binding site of tyrosene kinase p56 lck sh2 domain | LCK, PTPN6, PTPN22 | TDP1 1445/4885KMT2A 2476/4885MEN1 4192/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.