Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2E1 | P05181 | 1/20 | 0.68 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1442657 | 1.00 | CYP2E1 (0.68) | CYP2E1NR1I2HTT | |
| SCHEMBL671145 | 0.89 | CYP2E1 (0.65) | CYP2E1NR1I2 | |
| SCHEMBL10207387 | 0.89 | CYP2E1 (0.65) | CYP2E1NR1I2 | |
| SCHEMBL15498321 | 0.89 | CYP2E1 (0.74) | CYP2E1NR1I2 | |
| SCHEMBL10206082 | 0.89 | CYP2E1 (0.74) | CYP2E1NR1I2 | |
| SCHEMBL15130848 | 0.89 | CYP2E1 (0.64) | CYP2E1NR1I2 | |
| SCHEMBL9961535 | 0.88 | CYP2E1 (0.63) | CYP2E1NR1I2 | |
| SCHEMBL1440612 | 0.88 | CYP2E1 (0.63) | CYP2E1NR1I2 | |
| SCHEMBL15498290 | 0.88 | CYP2E1 (0.63) | CYP2E1NR1I2 | |
| SCHEMBL2219208 | 0.87 | NR1I2 (0.59) | CYP2E1NR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2507249-B1 | INHIBITORS OF FLAVIVIRIDAE VIRUSES | GILEAD SCIENCES INC (US) | 2015-11-11 | — | — | EP | disclosed |
| US-8765722-B2 | Inhibitors of flaviviridae viruses | GILEAD SCIENCES, INC. (US) | 2014-07-01 | — | — | US | disclosed |
| US-20130302280-A1 | INHIBITORS OF FLAVIVIRIDAE VIRUSES | GILEAD SCIENCES, INC. | 2013-11-14 | — | — | US | disclosed |
| US-8501714-B2 | Inhibitors of Flaviviridae viruses | GILEAD SCIENCES, INC. (US) | 2013-08-06 | — | — | US | disclosed |
| EP-2507249-A1 | INHIBITORS OF FLAVIVIRIDAE VIRUSES | Gilead Sciences, Inc. (US) | 2012-10-10 | — | — | EP | disclosed |
| US-20120156166-A1 | INHIBITORS OF FLAVIVIRIDAE VIRUSES | GILEAD SCIENCES, INC. (US) | 2012-06-21 | — | — | US | disclosed |
| WO-2011031669-A1 | INHIBITORS OF FLAVIVIRIDAE VIRUSES | GILEAD SCIENCES, INC. (US) | 2011-03-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130302280-A1 | INHIBITORS OF FLAVIVIRIDAE VIRUSES | HAVCR2, CYP2F1, CYP4F3 | CYP2E1 6/4885NR1I2 88/4885HTT 4622/4885 |
| US-20120156166-A1 | INHIBITORS OF FLAVIVIRIDAE VIRUSES | HAVCR2, CYP2F1, CYP4F3 | CYP2E1 6/4885NR1I2 88/4885HTT 4622/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.